| Effect of intralipid on the neonatal pulmonary bed: an echographic study. | |
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MedLine Citation:
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PMID: 3944677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of Intralipid infusion on pulmonary vascular resistance was studied prospectively by serial echocardiography on 13 occasions in six low birth weight infants. After 90 minutes of Intralipid infusion, the ratio of right ventricular preejection period to ejection time (RVPEP/ET) rose from 0.232 +/- 0.025 (mean +/- SD) to 0.285 +/- 0.035 (P = 0.0001). Of the 13 infusions studied, six (43%) resulted in RVPEP/ET values suggestive of pulmonary hypertension. Six LBW infants were observed over the same time period without Intralipid infusion, and RVPEP/ET did not change (0.209 +/- 0.035 vs 0.194 +/- 0.024). The increase in RVPEP/ET with Intralipid administration could not be explained by differences in preload or contractility, and most likely reflects an increase in pulmonary vascular tone. Caution in the use of Intralipid is recommended in infants who would be at particular risk from increased pulmonary vascular resistance. |
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Authors:
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T R Lloyd; M M Boucek |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 108 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-02-28 Completed Date: 1986-02-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 130-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Echocardiography* Fat Emulsions, Intravenous / adverse effects, pharmacology* Heart / drug effects Humans Hypertension, Pulmonary / chemically induced Infant, Newborn Infant, Premature* Lung / blood supply, drug effects* Prospective Studies Risk Vascular Resistance / drug effects* Vasoconstriction / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-2780203/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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