Document Detail

Effect of intralipid on the neonatal pulmonary bed: an echographic study.
MedLine Citation:
PMID:  3944677     Owner:  NLM     Status:  MEDLINE    
The effect of Intralipid infusion on pulmonary vascular resistance was studied prospectively by serial echocardiography on 13 occasions in six low birth weight infants. After 90 minutes of Intralipid infusion, the ratio of right ventricular preejection period to ejection time (RVPEP/ET) rose from 0.232 +/- 0.025 (mean +/- SD) to 0.285 +/- 0.035 (P = 0.0001). Of the 13 infusions studied, six (43%) resulted in RVPEP/ET values suggestive of pulmonary hypertension. Six LBW infants were observed over the same time period without Intralipid infusion, and RVPEP/ET did not change (0.209 +/- 0.035 vs 0.194 +/- 0.024). The increase in RVPEP/ET with Intralipid administration could not be explained by differences in preload or contractility, and most likely reflects an increase in pulmonary vascular tone. Caution in the use of Intralipid is recommended in infants who would be at particular risk from increased pulmonary vascular resistance.
T R Lloyd; M M Boucek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  108     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-02-28     Completed Date:  1986-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  AIM; IM    
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MeSH Terms
Fat Emulsions, Intravenous / adverse effects,  pharmacology*
Heart / drug effects
Hypertension, Pulmonary / chemically induced
Infant, Newborn
Infant, Premature*
Lung / blood supply,  drug effects*
Prospective Studies
Vascular Resistance / drug effects*
Vasoconstriction / drug effects
Grant Support
Reg. No./Substance:
0/Fat Emulsions, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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