Document Detail

Effect of intragastric infusions of ethanol and wine on serum gastrin concentration and gastric acid secretion.
MedLine Citation:
PMID:  3770365     Owner:  NLM     Status:  MEDLINE    
The effects of ethanol and wine on serum gastrin concentration and gastric acid secretion were evaluated in 13 normal volunteers. Solutions studied were pure ethanol (5%, 12%, and 36%), red wine, and white wine. Each solution contained 28 g of ethanol and each was administered as a slow, steady intragastric infusion to simulate normal ingestion of beverages. When compared to saline (control), none of the pure ethanol solutions increased serum gastrin concentration or gastric acid secretion significantly. In contrast, red and white wine (12% ethanol vol/vol) were potent stimulants of gastrin release and acid secretion when compared either to saline or pure 12% ethanol. Mean (+/- SEM) peak serum gastrin increases with 300 ml of red wine, white wine, saline, and pure 12% ethanol were 253 +/- 125, 182 +/- 91, 13 +/- 2, and 11 +/- 3 pg/ml, respectively (p less than 0.05 for red and white wine versus saline or 12% ethanol), and the mean peak acid outputs were 28.6 +/- 2.8, 27.9 +/- 1.9, 9.3 +/- 2.0, and 11.9 +/- 1.3 mmol/h, respectively (p less than 0.05 for red and white wine versus saline or 12% ethanol). We conclude that red and white wine stimulate gastric acid secretion, probably by enhanced release of gastrin, and that this effect is not due to the ethanol content of wine.
W L Peterson; C Barnett; J H Walsh
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  91     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1986-12-02     Completed Date:  1986-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1390-5     Citation Subset:  AIM; IM    
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MeSH Terms
Ethanol / administration & dosage,  pharmacology*
Gastric Juice / drug effects,  secretion*
Gastrins / blood*
Intubation, Gastrointestinal
Grant Support
Reg. No./Substance:
0/Gastrins; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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