| Effect of intraduodenal instillation of 1-phenyl-1-hydroxy-n-pentane on pancreatic exocrine secretions and immunoreactive secretion release in the rat. | |
| | |
MedLine Citation:
|
PMID: 6164622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pancreatic juice flow and amylase output, and the concentrations of immunoreactive secretin in portal and peripheral blood were simultaneously determined in anesthetized rats in response to intraduodenal instillation of 1-phenyl-1-hydroxy-n-pentane (PHP), a phenyl carbinol derivative induced from one of the constituents of Curcuma. PHP stimulated both pancreatic juice flow and amylase output and increased portal and jugular plasma secretin levels in a dose-related fashion. During intraduodenal instillation of PHP the pH in the second portion of the duodenum remained consistently above 6.3. Infusion of cyclic somatostatin at a dose of 5 microgram/kg/h significantly suppressed the PHP-induced secretin release, though pancreatic flow rate and amylase output were only slightly and insignificantly suppressed. These observations suggest that PHP release secretin by an acid independent mechanism but also stimulates the exocrine pancreas by a mechanism independent of secretin. |
| | |
Authors:
|
M Otsuki; C Sakamoto; A Ohki; H Yuu; S Baba |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 13 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1981 Feb |
Date Detail:
|
Created Date: 1981-07-09 Completed Date: 1981-07-09 Revised Date: 2009-02-19 |
Medline Journal Info:
|
Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 80-4 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amylases
/
secretion Animals Benzyl Alcohols / administration & dosage* Benzyl Compounds / administration & dosage* Dose-Response Relationship, Drug Duodenum Kinetics Male Pancreas / drug effects, secretion* Pancreatic Juice / secretion Rats Secretin / blood* Somatostatin / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Benzyl Alcohols; 0/Benzyl Compounds; 1393-25-5/Secretin; 51110-01-1/Somatostatin; 583-03-9/fenipentol; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Erythrokinetic study. Morphology of the bone marrow and blood following experimental induction of ma...
Next Document: Synthesis, 13C-NMR and CD study of the N-terminal tridecapeptide sequence of human fibroblast interf...