| Effect of an intraduodenal injection of fat on the activities of the adrenal efferent sympathetic nerve and the gastric efferent parasympathetic nerve in urethane-anesthetized rats. | |
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MedLine Citation:
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PMID: 20362017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nutrient information from the gastrointestinal tract to the brain plays a critical role in the regulation of appetite and energy homeostasis. The autonomic nervous system controls the functions of several tissues to regulate the energy homeostasis of the whole body. Autonomic nerve activity is influenced by environmental or exogenous changes in even a single tissue. In the present study, we investigated the effect of an intraduodenal injection of fat on the activities of the autonomic nerves innervating the adrenal gland and stomach in urethane-anesthetized rats. An intraduodenal injection of corn oil suppressed adrenal efferent sympathetic nerve activity (ASNA) and stimulated gastric efferent vagal nerve activity (GVNA). A lipase inhibitor, epsilon-polylysine, coinjected with corn oil completely suppressed the corn oil-induced changes in ASNA and GVNA. Further, an intraduodenal injection of fatty acid (linoleic acid) moderately suppressed ASNA and significantly stimulated GVNA; these results indicate that fat may affect autonomic nerve activity partly through the chemoreception of free fatty acids (FFAs), which are produced during the hydrolysis of fat (corn oil) by a pancreatic lipase, in the intestinal lumen. Furthermore, an intraduodenal injection of an intravenous fat emulsion with the same pH and osmotic pressure as the body fluid affected ASNA and GVNA in a similar manner as corn oil. These results suggest that intraduodenal fat suppresses ASNA and stimulates GVNA partly via the chemoreception of FFAs-the degradation products of fats-in the intestinal lumen. |
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Authors:
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Shigenobu Matsumura; Ai Eguchi; Nobuhide Kitabayashi; Mamoru Tanida; Jiao Shen; Yuko Horii; Katsuya Nagai; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-31 |
Journal Detail:
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Title: Neuroscience research Volume: 67 ISSN: 1872-8111 ISO Abbreviation: Neurosci. Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-09-13 Revised Date: 2010-12-11 |
Medline Journal Info:
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Nlm Unique ID: 8500749 Medline TA: Neurosci Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 236-44 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. |
Affiliation:
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Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Oiwake-cho, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan. sigenobu@kais.kyoto-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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innervation* Anesthesia Anesthetics, Intravenous Animals Dietary Fats / administration & dosage*, pharmacology* Duodenum / physiology* Efferent Pathways / drug effects* Enzyme Inhibitors / pharmacology Fat Emulsions, Intravenous / pharmacology Fatty Acids / administration & dosage, pharmacology Fatty Acids, Nonesterified / blood Indicators and Reagents Injections Lipase / antagonists & inhibitors Male Parasympathetic Nervous System / drug effects* Polylysine / pharmacology Rats Rats, Wistar Stomach / innervation* Sympathetic Nervous System / drug effects* Urethane |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Dietary Fats; 0/Enzyme Inhibitors; 0/Fat Emulsions, Intravenous; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Indicators and Reagents; 25104-18-1/Polylysine; 51-79-6/Urethane; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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