Document Detail

Effect of intracerebroventricularly infused glucagon on feeding behavior.
MedLine Citation:
PMID:  6514829     Owner:  NLM     Status:  MEDLINE    
Administration of pancreatic glucagon into 3rd cerebral ventricle of rats suppressed feeding with potency greater than 1000 times that of peripheral administration. A low dose of glucagon (5 ng) suppressed food intake mainly in short-term and slightly in long-term. A medium dose (25 ng) produced delayed feeding suppression. A high dose (100 ng) suppressed only short-term food intake. From this evidence, it is concluded that intracerebroventricular administration of physiological concentration of pancreatic glucagon suppresses short-term food intake through the hypothalamus. The possible mechanism of feeding suppression by glucagon is discussed.
A Inokuchi; Y Oomura; H Nishimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  33     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1985-01-31     Completed Date:  1985-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-400     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects*
Feeding Behavior / drug effects*
Glucagon / pharmacology*
Hypothalamus / drug effects
Injections, Intraventricular
Rats, Inbred Strains
Reg. No./Substance:

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