Document Detail


Effect of the intracerebroventricular and systemic administration of L-serine on the concentrations of D- and L-serine in several brain areas and periphery of rat.
MedLine Citation:
PMID:  12419539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To gain further insight into the metabolic mechanism of endogenous D-serine, the effect of the intracerebroventricular and intraperitoneal administration of L-serine on the concentrations of D- and L-serine in several brain areas and periphery was investigated. The intracerebroventricular injection of L-serine caused a rapid and marked increase in the L-serine levels in almost all brain regions of adult rats. This administration also produced a gradual increase in the D-serine levels in the forebrain, whereas a slight but significant elevation of D-serine was found in the cerebellum and pons-medulla. The intraperitoneal administration of L-serine caused a marked increase in the L-serine levels in all brain regions of both infant and adult rats. The treatment induced a significant augmentation of the D-serine levels in all brain regions of infant rats with higher concentrations in the cerebellum and cortex, whereas no significant change was observed in the cerebellum and pons-medulla of adult rats. These in vivo observation, together with the fact that immunohistochemical studies have indicated that both D-serine and serine racemase are highly concentrated in Bergmann glia of developing cerebellum, suggest that D-serine can be synthesized not only in the forebrain but also in the hindbrain by serine racemase. Furthermore, because the drastic decline in the cerebellar D-serine level coincides well with a dramatic increase in the cerebellar D-amino acid oxidase during early postnatal development, synthesized D-serine may be metabolized by D-amino acid oxidase in the hindbrain of adult rats.
Authors:
Atsushi Hashimoto
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  955     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-06     Completed Date:  2003-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  214-20     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1193, Japan. hashimot@is.icc.u-tokai.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Animals, Newborn
Brain / drug effects*,  metabolism*
Injections, Intraventricular
Male
Rats
Rats, Wistar
Serine / administration & dosage*,  biosynthesis,  metabolism*
Stereoisomerism
Chemical
Reg. No./Substance:
56-45-1/Serine
Comments/Corrections
Erratum In:
Brain Res. 2003 May 30;973(2):308

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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