Document Detail

Effect of intracerebrally injected aminophylline, vinpocetinum, vasoactive intestinal peptide and onion extract on breathing pattern of rats.
MedLine Citation:
PMID:  2588686     Owner:  NLM     Status:  MEDLINE    
Aminophylline or VIP (Vasoactive Intestinal Peptide) given ip. or iv. have marked bronchodilatory effects. The onion extracts protect guinea pigs as well as human patients against allergen-induced bronchial spasms (Dorsch et al.). Recently it has been shown that lipophilic components of onions seem to be responsible for the antiasthmatic effects. The purpose of this study was to investigate the effect of intracerebrally injected aminophylline (3 microM), Vinpocetinum (0.1 mg/kg), VIP (5 micrograms) and onion oils (30 microliters of extracts) on the respiratory center and on the resistance of lower airways of rats. The following respiratory parameters were evaluated: respiratory rate (RR), tidal volume (VT), mean inspiratory flow (Vin), respiratory minute volume (VE), and dynamic lung resistance (R). Respiratory rate was increased and values of all the other parameters were decreased after aminophylline treatment. VIP increased the tidal volume, minute ventilation and the respiratory drive. After injection of onion extracts the respiratory rate and the dynamic lung resistance decreased, but the tidal volume increased. The beneficial effects of onion oil are manifested not only peripherally acting on bronchial smooth muscle but via the reflexogenic pathways.
C Vertes; L A Debreczeni
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zeitschrift für Erkrankungen der Atmungsorgane     Volume:  173     ISSN:  0303-657X     ISO Abbreviation:  Z Erkr Atmungsorgane     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-26     Completed Date:  1989-12-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503239     Medline TA:  Z Erkr Atmungsorgane     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  134-7     Citation Subset:  IM    
Pathophysiological Research Unit, National Koranyi Institute for TBC and Pulmonology, Budapest/Hungary.
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MeSH Terms
Airway Resistance / drug effects*
Allium* / analysis
Aminophylline / pharmacology*
Lung Volume Measurements
Plant Extracts / pharmacology*
Pulmonary Ventilation / drug effects*
Rats, Inbred Strains
Respiratory Center / drug effects*
Vasoactive Intestinal Peptide / pharmacology*
Vasodilator Agents / pharmacology*
Vinca Alkaloids / pharmacology*
Reg. No./Substance:
0/Plant Extracts; 0/Vasodilator Agents; 0/Vinca Alkaloids; 317-34-0/Aminophylline; 37221-79-7/Vasoactive Intestinal Peptide; 42971-12-0/vinpocetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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