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EFFECT OF INTRABRONCHIAL INSUFFLATION OF ACID.
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MedLine Citation:
PMID:  19868439     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Acid administered to rabbits by intrabronchial insufflation causes an immediate and extreme damage of the lung tissue. Within certain limits the degree and extent of the injury vary according to the concentration of the acid. With the greater concentrations death occurs promptly, almost immediately, and the lethal process has associated with it a decreased permeability of the pulmonary vessels. The latter fact has been confirmed by postmortem arterial injections. With weaker solutions the results, grossly and histologically, resemble those noted after influenzal pneumonia and gas poisoning. Thus, there is destruction of the epithelium of the bronchioles, the alveolar ducts, and the alveoli. The extent of the damage to the alveolar walls varies. Exudation occurs into the alveolar, interstitial, perivascular, and peribronchial tissues. Primarily this exudate is serous, but a rapid deposition of fibrin occurs, and later polymorphonuclear leucocytes and erythrocytes accumulate. In different animals, or in different portions of the same lung, there may be consolidations of different types, serofibrinous, hemorrhagic, or purulent, with or without destruction of the alveolar walls. Subsequent changes relate to the organization of the exudate, necrosis, proliferation of the epithelium in the alveoli and bronchi, and, finally, to the regeneration of the pulmonary parenchyma. Experiments now in progress indicate that similar changes can be induced by various acids, both inorganic and organic. Experiments also show that similar changes are produced in other species of animals but that species differ in their resistance according to the acid and the concentration in which it is employed.
Authors:
M C Winternitz; G H Smith; F P McNamara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  32     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1920 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-06-22     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  -    
Affiliation:
Brady Laboratory of Pathology and Bacteriology of the School of Medicine, Yale University, New Haven.
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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1920, by The Rockefeller Institute for Medical Research New York
Received Day: 30 Month: 3 Year: 1920
Print publication date: Day: 31 Month: 7 Year: 1920
Volume: 32 Issue: 2
First Page: 199 Last Page: 204
ID: 2128272
PubMed Id: 19868439

EFFECT OF INTRABRONCHIAL INSUFFLATION OF ACID
M. C. Winternitz
G. H. Smith
F. P. McNamara
From the Brady Laboratory of Pathology and Bacteriology of the School of Medicine, Yale University, New Haven.


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