Document Detail

Effect of intrabiliary administration of Triton X-100 on biliary excretory function in the rat.
MedLine Citation:
PMID:  6431979     Owner:  NLM     Status:  MEDLINE    
Intrabiliary administration of Triton X-100 is of interest in producing effects on biliary tree permeability and canalicular biliary excretory function. Treatment with 0.4% Triton (40 microliter) was shown to increase the biliary excretion of intraportally administered [3H]sucrose. It also decreased recovery of [3H]sucrose given into the biliary tree. Thus, we concluded that Triton treatment increased biliary tree permeability. Using a different set of marker compounds, canalicular transport of bromphenol blue, [14C]morphine glucuronide and [3H]ouabain was found to be decreased. The fact that [3H] taurocholate excretion into bile was not affected whereas that of [3H]ouabain was lends support to the concept that taurocholate and ouabain are not transported by a common pathway.
E F Sweeney; J M Fujimoto
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  33     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-09-04     Completed Date:  1984-09-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2309-13     Citation Subset:  IM    
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MeSH Terms
Bile / drug effects*,  metabolism
Bile Ducts
Bromphenol Blue / metabolism
Detergents / pharmacology*
Injections, Intravenous
Mannitol / metabolism
Morphine / metabolism
Ouabain / metabolism
Polyethylene Glycols / pharmacology*
Portal Vein
Rats, Inbred Strains
Sucrose / metabolism
Surface-Active Agents / pharmacology*
Taurocholic Acid / metabolism
Grant Support
Reg. No./Substance:
0/Detergents; 0/Polyethylene Glycols; 0/Surface-Active Agents; 115-39-9/Bromphenol Blue; 57-27-2/Morphine; 57-50-1/Sucrose; 630-60-4/Ouabain; 69-65-8/Mannitol; 81-24-3/Taurocholic Acid; 9002-93-1/Octoxynol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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