Document Detail

Effect of intraamniotic vitamin A on palatal closure of fetal rats.
MedLine Citation:
PMID:  11272409     Owner:  NLM     Status:  MEDLINE    
On day 15 of gestation, intraamniotic vitamin A in a dose of 150 IU was administered to the fetal rats to examine its effect on palatal closure. Fetuses subjected to only amniocentesis acted as control for the study. The fetuses were recovered on day 19, 20 and 21, respectively. Vitamin A resulted in poor development of palatine shelves. There was no clear demarcation of the base and the free margins of the shelves were either rounded or blunted with poor attempt towards closure. In the vitamin A group, the incidence of cleft palate were similar in all three days while there was a gradual decline with increasing gestational age in the amniocentesis group. The results suggest that unlike amniocentesis, in vitamin A treated fetuses, there was no attempt towards a delayed closure of the palate.
C Mohanty; G Singh
Related Documents :
6936459 - Adjacency effects in developmental correlations among tooth organs in human fetuses.
3588539 - Prenatal diagnosis of the fragile x syndrome using fetal blood and amniotic fluid.
1489179 - Amelioration of zidovudine-induced fetal toxicity in pregnant mice.
16709209 - Detection of malformations in chromosomally normal fetuses by routine ultrasound at 12 ...
17582619 - Evaluation of 2407 fetuses in a turkish population.
7474059 - First and early second trimester diagnosis of anomalies of the central nervous system.
18488129 - Endosulfan and other organochlorine pesticide residues in maternal and cord blood in no...
818119 - Recognition of the hydropic fetus by gray scale ultrasound.
20164039 - Assessment of ghrelin, ghs-r, gh, and neurohormones in human fetal pituitary glands and...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  38     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2001-03-01     Completed Date:  2001-03-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  457-61     Citation Subset:  IM    
Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniocentesis / adverse effects
Amniotic Fluid
Cleft Palate / etiology,  pathology
Palate / drug effects*,  embryology*
Vitamin A / administration & dosage,  toxicity*
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute hepatotoxicity of DDT: effect on glucocorticoid receptors and serum transcortin.
Next Document:  Stereological study of rat spleen following acute ethanol treatment.