Document Detail

Effect of intraamniotic vitamin A on palatal closure of fetal rats.
MedLine Citation:
PMID:  11272409     Owner:  NLM     Status:  MEDLINE    
On day 15 of gestation, intraamniotic vitamin A in a dose of 150 IU was administered to the fetal rats to examine its effect on palatal closure. Fetuses subjected to only amniocentesis acted as control for the study. The fetuses were recovered on day 19, 20 and 21, respectively. Vitamin A resulted in poor development of palatine shelves. There was no clear demarcation of the base and the free margins of the shelves were either rounded or blunted with poor attempt towards closure. In the vitamin A group, the incidence of cleft palate were similar in all three days while there was a gradual decline with increasing gestational age in the amniocentesis group. The results suggest that unlike amniocentesis, in vitamin A treated fetuses, there was no attempt towards a delayed closure of the palate.
C Mohanty; G Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  38     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2001-03-01     Completed Date:  2001-03-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  457-61     Citation Subset:  IM    
Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.
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MeSH Terms
Amniocentesis / adverse effects
Amniotic Fluid
Cleft Palate / etiology,  pathology
Palate / drug effects*,  embryology*
Vitamin A / administration & dosage,  toxicity*
Reg. No./Substance:
11103-57-4/Vitamin A

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