Document Detail

Effect of intra-arterially induced alpha-receptor blockade upon resistance in collateral arteries in patients with occlusion of the superficial femoral artery.
MedLine Citation:
PMID:  6120777     Owner:  NLM     Status:  MEDLINE    
The effect of intra-arterially phentolamine inducing alpha-receptor blockade upon the resistance in collateral arteries bypassing an occlusion of the femoral artery was studied in five patients. The patients were placed on a tilt table and the measurements were performed with the patients in supine position and titled 40 degrees (head-up). Arterial blood pressure was measured directly in the brachial-common femoral-and popliteal artery. Relative blood flow was calculated as the relative change in arterio-venous oxygen saturation. Head-up tilt caused a decrease in blood flow of about 35% corresponding to an increase in total vascular resistance of 38%. Resistance in collateral arteries increased by 45%. In supine position alpha-receptor blockade reduced collateral resistance by 17%. However, the title-induced constriction of the collateral arteries was blocked by 87%. The results indicate that the constriction of the collateral arteries bypassing an occlusion of the superficial femoral artery is mainly mediated via sympathetic adrenergic vasoconstrictor fibres.
K Agerskov; O Henriksen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  1     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  385-93     Citation Subset:  IM; S    
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*
Arterial Occlusive Diseases / drug therapy*
Blood Flow Velocity
Collateral Circulation / drug effects*
Femoral Artery*
Middle Aged
Phentolamine / administration & dosage,  pharmacology,  therapeutic use
Vascular Resistance / drug effects*
Vasoconstriction / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 50-60-2/Phentolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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