Document Detail


Effect of intra-arterial infusion of glucose on secretory activity of isolated canine stomach.
MedLine Citation:
PMID:  896948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Totally isolated stomachs, perfused extracorporeally with homologous blood of living oxygenator dogs, were used for the study of gastric secretion. Pentagastrin or histamine were infused into the gastric artery alone or combined with a 30% solution of glucose. Hyperglycemia was associated with significant inhibition of gastric secretion. Volume, output of HCl and concentration of H+ in gastric secretion were decreased. Hyperglycemia induced also a significant increase in osmotic pressure of gastric secretion and gastric blood. Paired values of H+ and osmotic pressure of gastric secretion were analyzed by the method of least squares, using a computer. The regression line was given by the equation: osmotic pressure (mosm/kg)=311.2-0.167 X [H+] mEq/liter.
Authors:
K Kowalewski; A Kolodej
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  15     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1977  
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  324-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Gastric Acidity Determination
Gastric Juice / secretion*
Gastric Mucosa / drug effects*,  secretion
Glucose / administration & dosage,  pharmacology*
Histamine / administration & dosage,  pharmacology
Hyperglycemia
Injections, Intra-Arterial
Osmotic Pressure
Pentagastrin / administration & dosage,  pharmacology
Perfusion
Stomach / physiology
Chemical
Reg. No./Substance:
50-99-7/Glucose; 51-45-6/Histamine; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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