Document Detail

Effect of intra-abdominal pressure on hepatic microcirculation: Implications of the endothelin-1 receptor.
MedLine Citation:
PMID:  22908974     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE:   To investigate the effect of endothelin receptor A (ET(A) ) and endothelin receptor B (ET(B) ) blockade on liver microcirculation and oxygenation during intra-abdominal pressure (IAP) increase.
METHODS:   Fifteen anesthetized pigs were randomized to receive either nonselective endothelin-1 (ET-1) blocker tezosentan (TG, n = 7) or saline (CG, n = 8). Helium was insufflated to increase IAP from 0 to 25 mmHg. Stroke volume variability was maintained ≤ 12% with colloid infusion. Total liver blood flow (TLBF), hepatic microcirculatory blood flow (MBF), hepatic tissue oxygenation (HpO(2) ), hyaluronic acid and plasma disappearance rate (PDR) of indocyanine green (ICG) were recorded.
RESULTS:   TLBF remained mostly unaltered in both groups at low IAP and decreased only in CG at the IAP of 25 mmHg. As IAP increased, a significant decline in MBF was observed without correlation with cardiac output or TLBF. In CG, HpO(2) decreased as early as IAP of 10 mmHg to high levels of pressure. However, in TG the decrease was significant only at the IAP of 25 mmHg. PDR of ICG decreased in both groups at IAP of 25 mmHg (P = 0.046 and P = 0.009 in TG and CG, respectively). These changes correlated with MBF (r = 0.793).
CONCLUSION:   Blocking ET(A) and ET(B) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high IAP.
Gerard Sánchez-Etayo; Xavier Borrat; Bibiana Escobar; Amelia Hessheimer; Gonzalo Rodriguez-Laiz; Pilar Taura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  13     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  478-85     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Department of AnesthesiologySurgery, Hospital Clinic, Barcelona, Spain.
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