Document Detail

Effect of interpregnancy interval on infant low birth weight: a retrospective cohort study using the Michigan Maternally Linked Birth Database.
MedLine Citation:
PMID:  14509412     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the relationship between interpregnancy interval and low birth weight (LBW), using the retrospective cohort design. METHODS: We used the maternally linked Michigan livebirth data documented between 1989 and 2000 to evaluate LBW in relation to interpregnancy (i.e., delivery-to-conception) interval, overall and at levels of other reproductive risk factors. We fit separate logistic regression models for pairs of first-second, second-third, third-fourth, and fourth-fifth births to control for confounding. RESULTS: Of the 565,911 infants identified, 5.5% had LBW. Univariate and stratified analyses showed that the risk for LBW was lowest when the interpregnancy interval was 18-23 months, and increased with shorter or longer intervals. This J-shaped relationship persisted after controlling for all risk factors simultaneously. For example, among the first-second birth pairs, the adjusted odds ratios (AORs) for LBW associated with interpregnancy intervals <6, 24-59, 60-95, and 96-136 months were 1.4 (95% confidence interval [CI] = 1.3-1.5), 1.5 (95% CI = 1.3-1.6), 1.1 (95% CI = 1.0-1.1) and 1.5 (95% CI = 1.3-1.8), respectively, compared with an interval of 18-23 months. Among the second-third birth pairs, the AORs were 1.5 (95% CI = 1.3-1.6), 1.3 (95% CI = 1.2-1.4), 1.1 (95% CI = 1.0-1.1), and 1.6 (95% CI = 1.3-2.0), respectively. Among the third-fourth birth pairs, the AORs were 1.2 (95% CI = 1.1-1.4), 1.3 (95% CI = 1.1-1.5), 1.0 (95% CI = 0.9-1.1), and 1.4 (95% CI = 1.0-2.0), respectively. Among the fourth-fifth birth pairs, the AORs were 1.3 (95% CI = 1.1-1.6), 1.2 (95% CI = 0.9-1.5), 1.1 (95% CI = 1.0-1.4), and 1.3 (95% CI = 0.8-2.3), respectively. The population attributable risk associated with interpregnancy intervals shorter than 18 months or longer than 23 months was 9.4%. CONCLUSION: These data suggest that spacing pregnancies appropriately could be used as a strategy for preventing LBW.
Bao-Ping Zhu; Thu Le
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Maternal and child health journal     Volume:  7     ISSN:  1092-7875     ISO Abbreviation:  Matern Child Health J     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-25     Completed Date:  2004-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9715672     Medline TA:  Matern Child Health J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-78     Citation Subset:  IM    
Applied Sciences Branch, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ZHUB@DHSS.STATE.MO.US
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MeSH Terms
Birth Intervals* / statistics & numerical data
Cohort Studies
Databases, Factual*
Infant, Low Birth Weight*
Infant, Newborn
Public Health Informatics*
Retrospective Studies

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