Document Detail

Effect of interpregnancy interval on adverse perinatal outcomes--a national study.
MedLine Citation:
PMID:  19913144     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The interpregnancy interval (IPI) has been reported to influence the outcome of pregnancy and birth. We performed a national study in Israel to determine the impact of IPI on multiple adverse perinatal outcomes. STUDY DESIGN: This longitudinal cohort study used birth certificates of siblings born to the same biological mother, with at least one previous birth and a subsequent singleton pregnancy. Adverse pregnancy outcomes included preterm delivery, very preterm birth, small for gestational age (SGA), very SGA (VSGA), early neonatal death and major congenital malformations. Multivariate logistic regression was performed for each outcome. RESULTS: The study included 440,838 of a total of 846,845 reported live births in Israel over 5 years; excluded were primiparas (32%), multifetal births (4.9%) and those with incomplete data (10.9%). For IPIs shorter than 6 months, there were significantly increased risks for preterm birth (OR=1.23), SGA (OR=1.14), VSGA (OR=1.15), early neonatal death (OR=1.62) and congenital malformations (OR=1.14). Intervals of 60 months or longer had higher risks for preterm birth (OR=1.39) and VSGA (OR=1.16). CONCLUSION: Optimal IPI recommendation of >11 months is an accessible and low-cost means to improve multiple adverse perinatal outcomes.
Sorina Grisaru-Granovsky; Ethel-Sherry Gordon; Ziona Haklai; Arnon Samueloff; Michael M Schimmel
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Publication Detail:
Type:  Journal Article     Date:  2009-07-22
Journal Detail:
Title:  Contraception     Volume:  80     ISSN:  1879-0518     ISO Abbreviation:  Contraception     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  512-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem 91031, Israel.
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MeSH Terms
Birth Certificates
Birth Intervals*
Gestational Age
Infant, Newborn
Infant, Small for Gestational Age
Longitudinal Studies
Maternal Age
Multivariate Analysis
Odds Ratio
Pregnancy Outcome*
Premature Birth
Prospective Studies
Regression Analysis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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