Document Detail

Effect of intermittent positive pressure application on the bulk modulus of the developing rabbit trachea.
MedLine Citation:
PMID:  7025137     Owner:  NLM     Status:  MEDLINE    
Tracheal dimension, pressure-volume relationships and bulk modulus (K) were determined in excised fetal and adult rabbit tracheal segments before and after application of intermittent positive pressure (IPP) which was 0--25 cm H2O pressure, at 30 cycles/min, and for a duration of 60 min. Both tracheal elastic behavior and dimensions underwent dramatic changes following IPP. At 21, 27, 31 days gestation age, the bulk modulus, K, of the rabbit trachea approximated those of the adult control values. However, the adult values of K did not vary significantly after IPP. The associated increase in tracheal dimensions were also related to the maturity of the animal. Significant structural and functional barotrauma is thus sustained by immature airways, and may account for the tracheal deformation frequently observed as a result of IPP.
V K Bhutani; T H Shaffer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  41     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  192-8     Citation Subset:  IM    
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MeSH Terms
Barotrauma / etiology
Fetus / physiology*
Gestational Age
Intermittent Positive-Pressure Ventilation / adverse effects*
Organ Culture Techniques
Positive-Pressure Respiration / adverse effects*
Tensile Strength
Trachea / injuries,  physiology*,  physiopathology
Grant Support

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