Document Detail

Effect of intermittent infusions of glucose-containing crystalloid cardioplegic solution on myocardial tissue lactic acid and recovery of contractility.
MedLine Citation:
PMID:  6727413     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine the effects of single or intermittent infusions of cardioplegic solution with glucose (5 gm/L) or without glucose on myocardial tissue lactic acid and recovery of myocardial contractility following 80 minutes of total ischemia at 28 degrees C in the isolated, blood-perfused, beating rabbit heart. Ischemia without cardioplegia increased tissue lactic acid (6.79 mg/gm tissue) above the control value (0.9 mg/gm tissue), p less than 0.0025). Lactic acid following single infusions with (4.19 mg/gm tissue) or without glucose (3.67 mg/gm tissue) was significantly greater (p less than 0.0025) than tissue lactic acid following intermittent infusions with (1.06 mg/gm tissue) or without glucose (1.05 mg/gm tissue). Cardioplegic arrest in all cases significantly decreased tissue lactate accumulation when compared to arrest without cardioplegia (p less than 0.01). The decrease in myocardial contractility demonstrated when no cardioplegic protection was employed (86% recovery) was completely eliminated (100% recovery) with a single-bolus infusion of cardioplegic solution containing glucose (p less 0.025). Intermittent infusions of cardioplegic solution containing glucose (92% recovery) and single infusions without glucose (93% recovery) also improved recovery of contractility following ischemia, but the results were not statistically significant.
E J Guilbeau; L K Moore; A J Viole; T R Mathis; A J Switzer; T A Brandon; M Martin; R L Fisk
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  87     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-16     Completed Date:  1984-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  920-9     Citation Subset:  AIM; IM    
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MeSH Terms
Coronary Disease / metabolism,  physiopathology
Glucose / pharmacology
Lactates / metabolism*
Lactic Acid
Myocardial Contraction / drug effects*
Myocardium / metabolism*
Potassium / administration & dosage,  pharmacology*
Potassium Compounds*
Grant Support
1-R01-HL25924-01A2/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Lactates; 0/Potassium Compounds; 0/potassium cardioplegic solution; 50-21-5/Lactic Acid; 50-99-7/Glucose; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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