| Effect of intermittent administration of adiponectin on bone regeneration following mandibular osteodistraction in rabbits. | |
| | |
MedLine Citation:
|
PMID: 21344499 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Adiponectin, a protein hormone produced and secreted exclusively by adipocytes, was reported to increase bone mass and stimulate angiogenesis. However, the effect of adiponectin on bone regeneration following distraction osteogenesis has not yet been reported. In this study, rapid unilateral mandibular osteodistraction (distraction rate = 2 mm/day) was applied in 24 New Zealand white rabbits. The animals were then randomly divided into groups A and B (n = 12 for each group). At the 1st, 3rd, and 5th day of the distraction, 200 µl PBS and 200 µl PBS contained 2 µg rh-adiponectin was intermittently injected into the distraction gap in groups A and B, respectively. At 6 weeks after the end of distraction, the rabbits were sacrificed, and the distracted mandibles were harvested and processed for radiography, dual energy X-ray absorptiometry (DXA), micro-CT, histology, and three-point bend testing. Under a rapid distraction, immature bone formation was seen in the distracted callus from group A. However, much greater bone formation and higher bone mineral density (BMD) and bone mineral content (BMC) of the distracted callus were observed in group B. Such finding was confirmed by histological, micro-CT examinations, and mechanical strength test. The results of this study suggest that intermittent administration of adiponectin can promote bone regeneration following rapid mandibular osteodistraction in rabbits. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res. |
| | |
Authors:
|
Xiaowen Jiang; Donghui Song; Bin Ye; Xuemei Wang; Guodong Song; Shoukang Yang; Jing Hu |
Related Documents
:
|
21419549 - Volume changes of grafted autogenous bone in sinus augmentation procedure. 9083289 - Bone health of adult hemodialysis patients is related to vitamin k status. 21558929 - Correction of alveolar cleft with calcium-based bone substitutes. 20861819 - Recent progress in the treatment of vascular calcification. 11314379 - Calcium sulfate bone void filler: a review and a look ahead. 6451429 - Deconvolution analysis of 99mtc-methylene diphosphonate kinetics in metabolic bone dise... 22942169 - Injury in elite new zealand cricketers 2002-2008: descriptive epidemiology. 3339059 - Stanmore total hip replacement. a nine- to ten-year follow-up. 8368419 - Effect of anterior cruciate ligament graft tensioning direction, magnitude, and flexion... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-22 |
Journal Detail:
|
Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: - ISSN: 1554-527X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Orthopaedic Research Society. |
Affiliation:
|
State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University, Chengdu, China; Department of Stomatology, the First People's Hospital of Chenzhou, Chenzhou, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Combined effects of TNF-?, IL-1?, and HIF-1? on MMP-2 production in ACL fibroblasts under mechanical...
Next Document: Association between type-three metabotropic glutamate receptor gene (GRM3) variants and symptom pre...