| Effect of intermittent acid and pepsin exposure on burned esophageal mucosa. | |
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MedLine Citation:
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PMID: 8801815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine if gastroesophageal reflux affects the healing of esophageal mucosa damaged by alkaline substances. MATERIALS AND METHODS: In a rabbit model, the effects of intermittent acid and pepsin exposure (thereby mimicking gastroesophageal reflux) on post-caustic-burn esophageal mucosa were examined. Exposures were group I (n = 9), sodium hydroxide exposure alone; group II (n = 9), daily acid and pepsin exposure; and group III (n = 8), sodium hydroxide, then daily acid and pepsin exposure. After 3 weeks, the animals were killed and their esophagi examined. RESULTS: Grossly, specimens in group II appeared normal; specimens in groups I and III were abnormal, displaying some scar tissue, but were not significantly different. Histologically, the differences between groups I and III approached significance. Increased numbers of intraepithelial eosinophils were seen in those specimens exposed to reflux. CONCLUSIONS: Gastroesophageal reflux may retard the healing of injured esophageal mucosa and should be studied further in an effort to improve the care of patients who sustain alkaline esophageal burns. |
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Authors:
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A H Messner; J D Browne; K R Geisinger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of otolaryngology Volume: 17 ISSN: 0196-0709 ISO Abbreviation: Am J Otolaryngol Publication Date: 1996 Jan-Feb |
Date Detail:
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Created Date: 1996-10-02 Completed Date: 1996-10-02 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 45-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1034, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Burns, Chemical / etiology, pathology*, physiopathology Caustics / adverse effects Disease Models, Animal Esophagus / pathology*, physiopathology Gastric Acid / physiology* Gastroesophageal Reflux / physiopathology* Pepsin A / physiology* Pilot Projects Rabbits Wound Healing / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Caustics; EC 3.4.23.1/Pepsin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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