Document Detail


Effect of intermittent acid and pepsin exposure on burned esophageal mucosa.
MedLine Citation:
PMID:  8801815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine if gastroesophageal reflux affects the healing of esophageal mucosa damaged by alkaline substances. MATERIALS AND METHODS: In a rabbit model, the effects of intermittent acid and pepsin exposure (thereby mimicking gastroesophageal reflux) on post-caustic-burn esophageal mucosa were examined. Exposures were group I (n = 9), sodium hydroxide exposure alone; group II (n = 9), daily acid and pepsin exposure; and group III (n = 8), sodium hydroxide, then daily acid and pepsin exposure. After 3 weeks, the animals were killed and their esophagi examined. RESULTS: Grossly, specimens in group II appeared normal; specimens in groups I and III were abnormal, displaying some scar tissue, but were not significantly different. Histologically, the differences between groups I and III approached significance. Increased numbers of intraepithelial eosinophils were seen in those specimens exposed to reflux. CONCLUSIONS: Gastroesophageal reflux may retard the healing of injured esophageal mucosa and should be studied further in an effort to improve the care of patients who sustain alkaline esophageal burns.
Authors:
A H Messner; J D Browne; K R Geisinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of otolaryngology     Volume:  17     ISSN:  0196-0709     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    1996 Jan-Feb
Date Detail:
Created Date:  1996-10-02     Completed Date:  1996-10-02     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1034, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Burns, Chemical / etiology,  pathology*,  physiopathology
Caustics / adverse effects
Disease Models, Animal
Esophagus / pathology*,  physiopathology
Gastric Acid / physiology*
Gastroesophageal Reflux / physiopathology*
Pepsin A / physiology*
Pilot Projects
Rabbits
Wound Healing / physiology*
Chemical
Reg. No./Substance:
0/Caustics; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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