Document Detail

Effect of interferon-gamma treatment on interstitial pneumonia in a patient with severe combined immunodeficiency.
MedLine Citation:
PMID:  1812657     Owner:  NLM     Status:  MEDLINE    
In severe combined immunodeficiency disease, both T and B cell functions are diminished or absent and affected usually succumb to overwhelming infection within the first year of life. We are reporting a case with severe combined immunodeficiency, Swiss type who suffered from interstitial pneumonia which cleared by treatment with recombinant human interferon gamma. In this case, we don't know the exact mechanism which caused the clearing of the interstitial pneumonia. However, we can speculate that antiviral action and activated macrophages or monocytes, through the recombinant human interferon gamma, might exert its effect on interstitial pneumonia. Though we should extend its application to more cases of SCID with interstitial pneumonia, this report may suggests a new application for interferon-gamma as a potential corrective and therapeutic agent for interstitial pneumonia in congenital immunodeficiency diseases.
K H Kim; H Y Kang; D S Kim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Yonsei medical journal     Volume:  32     ISSN:  0513-5796     ISO Abbreviation:  Yonsei Med. J.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0414003     Medline TA:  Yonsei Med J     Country:  KOREA    
Other Details:
Languages:  eng     Pagination:  356-61     Citation Subset:  IM    
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
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MeSH Terms
Interferon-gamma, Recombinant / therapeutic use*
Pulmonary Fibrosis / therapy*
Severe Combined Immunodeficiency / complications*
Reg. No./Substance:
0/Interferon-gamma, Recombinant

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