Document Detail

Effect of interaction between left ventricular dysfunction and endothelial function in hypertension.
MedLine Citation:
PMID:  17147919     Owner:  NLM     Status:  MEDLINE    
Hypertension, one of the most important risk factors for cardiovascular diseases, is associated with both left ventricular hypertrophy and endothelial dysfunction. Both have been recently recognized as independent predictors of clinical events in different groups of patients. In fact, a dysfunctioning endothelium loses its antiatherosclerotic and antithrombotic action, and, therefore, promotes the atherosclerotic process. Similarly, cardiac hypertrophy is recognized as a powerful and independent risk factor for cardiovascular morbidity and mortality because it predisposes to arrhythmias and maximizes the consequences of acute myocardial ischemia. Recently, an evident interaction has been demonstrated between endothelial dysfunction and left ventricular mass. In particular, the coexistence of both left ventricular hypertrophy and endothelial dysfunction almost doubles the risk for future vascular events in hypertensives. Thus, in hypertensive patients, it is clinically useful to choose an aggressive therapeutic strategy--to reduce left ventricular mass and to improve endothelial function.
Angela Sciacqua; Francesco Borrello; Marco Vatrano; Rosa Daniela Grembiale; Francesco Perticone
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  8     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-12-06     Completed Date:  2007-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-8     Citation Subset:  IM    
Department of Medicina Sperimentale e Clinica, Policlinico Mater Domini, Via Tommaso Campanella, 88100 Catanzaro, Italy.
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MeSH Terms
Coronary Artery Disease / etiology,  physiopathology*,  prevention & control
Endothelium, Vascular / physiopathology*
Hypertension / complications*,  physiopathology*
Hypertrophy, Left Ventricular / complications,  physiopathology*
Risk Factors
Ventricular Dysfunction, Left / complications,  physiopathology*

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