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Effect of intensive lipid lowering on cardiovascular outcome in patients with and without inflammatory joint disease.
MedLine Citation:
PMID:  22576673     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: We examined the effect of intensive lipid lowering in patients with inflammatory joint disease (IJD) [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] on a composite cardiovascular outcome (CV disease; CVD) consisting of mortality and morbidity endpoint by post hoc analysis of two prospective CV secondary (TNT and IDEAL) endpoint statin trials. METHODS: Of the 18889 patients participating in these 2 trials, 199 had RA, 46 AS, and 35 PsA. Intensive lipid lowering regimens were with atorvastatin 80 mg, conventional/low regimens with atorvastatin 10 mg or simvastatin 20-40mg. Median follow-up was nearly 5 years. Lipid levels and changes were examined with analyses of covariance. Effect on CVD was examined by Cox regression analyses and heterogeneity tests were performed. RESULTS: Patients with RA and AS had lower baseline cholesterol compared to non-IJD (LSMeans ± SE180.7± 2.3 and 176.5 ± 4.7 vs. 185.6 ± 0.2 mg/dL; p=0.03 and p=0.05, respectively). The lipid reduction by statins was comparable in patients with and without IJD, and reduced risk of CVD was overall 20% in both IJD and non-IJD. CONCLUSION: Patients with and without IJD had comparable lipid lowering effect and risk reduction of CVD after intensive treatment with statins. © 2012 American College of Rheumatology.
Authors:
Anne Grete Semb; Tore K Kvien; David Demicco; Rana Fayyad; Chuan-Chuan Wun; John Larosa; John Betteridge; Terje R Pedersen; Ingar Holme
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-10
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. anne.semb@yahoo.no.
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