Document Detail

Effect of insulin treatment on the blood-retinal barrier in rats with streptozocin-induced diabetes.
MedLine Citation:
PMID:  6344848     Owner:  NLM     Status:  MEDLINE    
Eighteen rats were made diabetic with a single intravenous dose of streptozocin; 16 rats served as nondiabetic controls. Fluorescein sodium was injected into the tail vein for fluorophotometry. After insulin therapy, metabolic control was improved in the diabetic animals, but normoglycemia was not achieved. The vitreous fluorescein level in diabetic animals was significantly higher than in controls before insulin treatment, but it decreased after six to seven days of insulin therapy. There was no significant alteration of the fluorescein concentration in the vitreous body of the controls when vitreous fluorophotometry was repeated after six to seven days. The plasma fluorescein concentration was lower in the diabetic than in the nondiabetic animals and unaltered after insulin treatment. The results imply that the dysfunction of the blood-retinal barrier in the diabetic rats is reversible by insulin therapy. It is probably related to the diabetic state and not to a toxic effect of streptozocin.
A Kernell; H Arnqvist
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  101     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  968-70     Citation Subset:  AIM; IM    
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MeSH Terms
Capillary Permeability / drug effects*
Diabetes Mellitus, Experimental / drug therapy*,  metabolism,  physiopathology
Insulin / therapeutic use*
Rats, Inbred Strains
Retina / drug effects*,  physiology
Reg. No./Substance:

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