Document Detail

Effect of insulin resistance on postprandial elevations of remnant lipoprotein concentrations in postmenopausal women.
MedLine Citation:
PMID:  11684526     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Questions remain as to why postmenopausal women are at a higher risk of coronary artery disease (CAD) than are premenopausal women. Studies have shown that plasma concentrations of remnant lipoproteins (RLPs) are elevated in patients with CAD and that increases in plasma RLP concentrations may be related to variations in insulin-mediated glucose disposal. OBJECTIVE: We sought to evaluate the possibility that postprandial accumulation of plasma RLPs will be accentuated in insulin-resistant, postmenopausal women. DESIGN: Postmenopausal women were divided into insulin-sensitive (n = 15) and insulin-resistant (n = 15) groups according to their steady state plasma glucose concentrations in response to a 180-min infusion of octreotide, insulin, and glucose. Plasma insulin, triacylglycerol, and RLP-cholesterol concentrations were measured either hourly (insulin) or every 2 h (triacylglycerol and RLP cholesterol) for 8 h, before and after breakfast (0800) and lunch (1200). RESULTS: By selection, insulin-resistant women had higher steady state plasma glucose concentrations than did insulin-sensitive women (10.8 +/- 0.5 compared with 4.1 +/- 5 mmol/L, respectively; P < 0.001), associated with higher fasting triacylglycerol (1.58 +/- 0.04 compared with 1.00 +/- 0.03 mmol/L; P = 0.01) and lower HDL-cholesterol (1.06 +/- 0.08 compared with 1.34 +/- 0.05; P = 0.01) concentrations. In addition, measurements of daylong concentrations of insulin, triacylglycerol, and RLP cholesterol were also significantly greater in insulin-resistant than in insulin-sensitive women (P < 0.001). CONCLUSIONS: Postprandial accumulation of RLPs is accentuated in insulin-resistant, postmenopausal women. This may contribute to the increased risk of CAD in these individuals.
H S Kim; F Abbasi; C Lamendola; T McLaughlin; G M Reaven
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  74     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2001-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-5     Citation Subset:  AIM; IM    
Department of Medicine, Stanford University School of Medicine, California 94305, USA.
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MeSH Terms
Blood Glucose / analysis
Cholesterol / blood
Cholesterol, HDL / blood
Chylomicrons / blood
Coronary Artery Disease / blood*
Insulin / blood
Insulin Resistance*
Lipoproteins / blood*
Lipoproteins, VLDL / blood
Middle Aged
Postmenopause / blood*
Postprandial Period*
Time Factors
Triglycerides / blood
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Chylomicrons; 0/Lipoproteins; 0/Lipoproteins, VLDL; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol

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