Document Detail

Effect of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozocin-induced diabetes.
MedLine Citation:
PMID:  3514329     Owner:  NLM     Status:  MEDLINE    
The effect of insulin or glutathione treatment on glutathione content of liver and jejunal mucosa and on superoxide dismutase (SOD) activity of liver, kidney, and erythrocytes was investigated in pair-fed animals with streptozocin (STZ)-induced diabetes. Diabetes lowered hepatic glutathione concentration, but glutathione concentration of the jejunal mucosa was not affected. Insulin, but not oral glutathione, restored hepatic glutathione concentration to normal levels. Diabetes depressed activity of the cytosolic form of SOD in liver, kidney, and erythrocyte. Treatment of diabetic rats with oral glutathione or intramuscular insulin increased cytosolic SOD activity of renal cortex and liver (but not erythrocytes) to control levels. These results suggest a link between glutathione metabolism and cytosolic SOD activity in diabetes.
D Loven; H Schedl; H Wilson; T T Daabees; L D Stegink; M Diekus; L Oberley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  35     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-05-22     Completed Date:  1986-05-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  AIM; IM    
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MeSH Terms
Diabetes Mellitus, Experimental / enzymology*,  metabolism
Erythrocytes / enzymology
Glutathione / analysis,  pharmacology*
Insulin / pharmacology*
Intestinal Mucosa / analysis
Jejunum / analysis
Kidney / enzymology
Liver / analysis,  enzymology
Rats, Inbred Strains
Superoxide Dismutase / metabolism*
Grant Support
Reg. No./Substance:
11061-68-0/Insulin; 70-18-8/Glutathione; EC Dismutase

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