Document Detail

Effect of inspired oxygen on the cardiovascular effects of protamine after cardiopulmonary bypass.
MedLine Citation:
PMID:  7488479     Owner:  NLM     Status:  MEDLINE    
We have performed a randomized prospective study of the effects of inspired oxygen fraction (FIO2) on the haemodynamic changes after protamine infusion. Thirty-four patients undergoing first time coronary artery bypass surgery were allocated randomly to receive either an FIO2 of 1.0 (group O) or 0.35 (group A) after cardiopulmonary bypass. Before and after infusion of protamine, haemodynamic measurements were obtained, including mean arterial pressure (MAP), mean pulmonary artery pressure, central venous pressure, pulmonary capillary wedge pressure (PCWP), cardiac index (CI), pulmonary vascular resistance index (PVRI) and systemic vascular resistance index (SVRI). In group O, there were increases in mean MAP (8%), PVRI (48%) and SVRI (18%), and decreases in mean CI (10%) and PCWP (15%). Group A showed changes of 0%, -8%, -6%, +3% and +32%, respectively. We found a significant difference between groups in changes in PVRI (P < 0.0001), SVRI (P < 0.01), CI (P < 0.05) and PCWP (P < 0.001). During infusion of protamine, 31% of patients in group O and 6% of patients in group A had a decrease in systolic arterial pressure to less than 80 mm Hg (ns, chi-square test). These observations suggest that FIO2 alters the haemodynamic effects of protamine.
D Lomax; S Valentine
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  75     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-01-04     Completed Date:  1996-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  413-6     Citation Subset:  IM    
Royal Perth Hospital, Western Australia.
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MeSH Terms
Blood Pressure / drug effects
Cardiopulmonary Bypass*
Drug Interactions
Hemodynamics / drug effects*
Heparin Antagonists / pharmacology*
Middle Aged
Oxygen / pharmacology*
Prospective Studies
Protamines / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Heparin Antagonists; 0/Protamines; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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