Document Detail

Effect of insecticide-treated bed nets on haemoglobin values, prevalence and multiplicity of infection with Plasmodium falciparum in a randomized controlled trial in Tanzania.
MedLine Citation:
PMID:  10450426     Owner:  NLM     Status:  MEDLINE    
A randomized controlled trial of insecticide-treated bed nets (ITNs) was conducted in an area of high malaria transmission in Tanzania in order to assess the effects of ITNs on infection and anaemia. One hundred and twenty-two children, aged 5 to 24 months, were randomly allocated to 2 groups, one of which received ITNs. Outcome measures were assessed in 6 consecutive months with monthly cross-sectional surveys. These measures were haemoglobin values, Plasmodium falciparum prevalence and density, and multiplicity of infection determined by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) of the msp2 locus. There was a significant increase in mean heamoglobin values and a significant decrease of 16.4% in microscopically determined P. falciparum prevalence in children in the ITN group six months after the start of the trial. Both effects were more pronounced in younger children. However, no significant difference was observed in parasite density or multiplicity of infection among infected children. Comparison with PCR results indicated that microscopically subpatent parasitaemia was more frequently found in children in the ITN group. This, together with the observed similar multiplicity in the 2 groups, suggests that infections are maintained despite ITN use, owing to the chronicity of infections. This study shows that ITNs reduce the risk of anaemia in highly exposed young children. The virtually unchanged multiplicity of infection indicates that the potentially protective concomitant immunity is not compromised.
N Fraser-Hurt; I Felger; D Edoh; S Steiger; M Mashaka; H Masanja; T Smith; F Mbena; H P Beck
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  93 Suppl 1     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Ifakara Health Research and Development Centre, Tanzania.
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MeSH Terms
Anemia, Iron-Deficiency / prevention & control
Bedding and Linens*
Cross-Sectional Studies
Hemoglobins / analysis
Malaria, Falciparum / blood*,  epidemiology,  prevention & control
Polymorphism, Restriction Fragment Length
Tanzania / epidemiology
Reg. No./Substance:
0/Hemoglobins; 0/Insecticides

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