Document Detail

Effect of inotropic interventions on rate of change of ventricular diastolic dimensions.
MedLine Citation:
PMID:  7282946     Owner:  NLM     Status:  MEDLINE    
The effects of inotropic interventions upon the maximal rate of change of left ventricular (LV) wall thickness and internal diameter during early diastole were measured in nine open-chest dogs by ultrasonic-dimension gauges. Isoproterenol increased the maximal rate of wall thickening during systole from 28 +/- 3 to 48 +/- 5 (SE) mm/s (P less than 0.001), whereas it had no effect on the maximal rate of wall thinning during early diastole, 40 +/- 4 vs. 42 +/- 4 mm/s [not significant (NS)]. Isoproterenol also increased the maximal rate of reduction of the LV diameter during systole from 87 +/- 6 to 125 +/- 8 mm/s (P less than 0.001), whereas it had little effect on the maximal rate of increase of the diameter during early diastole, 79 +/- 6 vs. 87 +/- 4 mm/s (NS). Similarly, propranolol had a direct effect on the maximal rate of wall thickening and LV diameter reduction during systole, but it had little or no effect on their counterparts during early diastole. These observations support the concept that alterations of the contractile state need not be accompanied by a concomitant effect on relaxation.
H N Sabbah; P D Stein
Related Documents :
18002126 - Effects of aging and exercise training on the common carotid blood velocities in health...
19286956 - Detrimental effect of combined exercise training and enos overexpression on cardiac fun...
8340996 - Effects of volume and pressure overloads and myocardial hypertrophy on exercise-induced...
7801856 - Effects of left ventricular diastolic dysfunction on exercise capacity three to six wee...
7546116 - Evaluation of three nonwoven sponges in the debridement of chronic wounds.
21109916 - Predictive value of resting heart rate for cardiovascular and all-cause mortality.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  241     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H376-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects
Diastole / drug effects*
Heart Ventricles / drug effects
Isoproterenol / pharmacology*
Muscle Relaxation / drug effects
Myocardial Contraction / drug effects*
Propranolol / pharmacology*
Ventricular Function
Grant Support
Reg. No./Substance:
525-66-6/Propranolol; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Detection of delayed ventricular activation on the body surface in dogs.
Next Document:  Comparison of fast and slow pressor effects of angiotensin II in the conscious rat.