| Effect of inner ear blood flow changes on the endolymphatic sac. | |
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MedLine Citation:
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PMID: 18607967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSIONS: That the endolymphatic sac (ES) reacts to changes in inner ear blood flow may be important for homeostasis of the inner ear fluid volume and pressure. OBJECTIVES: To elucidate the effect of changes in inner ear blood flow on the ES and to learn more about the volume and pressure regulatory function of the ES. MATERIALS AND METHODS: Epinephrine or sodium nitroprusside (SNP) was injected into the middle ear cavity of adult CBA/J mice. The ES were analyzed morphologically by light microscopy. RESULTS: Epinephrine reduced the luminal size of the ES leading to an accumulation of intraluminal homogeneous substance. Injection of SNP increased the size of the ES lumen, accompanied by a collapse of the lateral intercellular space (LIS) and dense perisaccular tissue. These changes were almost reversed 4 h after injection. |
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Authors:
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Nana Akagi; Masaya Takumida; Matti Anniko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 128 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-02-25 Completed Date: 2009-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: Norway |
Other Details:
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Languages: eng Pagination: 1187-95 Citation Subset: IM |
Affiliation:
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Hiroshima University School of Medicine, Hiroshima, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cochlea / blood supply Ear, Inner / blood supply* Endolymphatic Duct / cytology, drug effects Endolymphatic Sac / cytology*, drug effects, physiology Epinephrine / pharmacology Mice Mice, Inbred CBA Nitroprusside / pharmacology Regional Blood Flow / drug effects Stria Vascularis / cytology, drug effects Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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