Document Detail


Effect of initial biopsy procedure on prognosis in Stage 1 invasive cutaneous malignant melanoma: review of 1086 patients.
MedLine Citation:
PMID:  1933198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After treatment for primary clinical Stage 1 invasive cutaneous malignant melanoma, 1086 patients were followed for a minimum of 5 years from initial operation. Patient data were retrieved from the unit's melanoma registry; 96 (8.8 per cent) were treated initially by incisional biopsy, 292 (26.9 per cent) by narrow margin excision biopsy and 698 (64.3 per cent) by wide margin excision. Logistic regression analysis was performed to assess the statistical significance of the association between the various factors. The method of initial biopsy was related to maximal tumour thickness, age, and sex. Incisional biopsy rendered 38 out of 96 (40 per cent) lesions not fully assessable on current histopathological criteria, significantly higher than for the other biopsy techniques (P less than 0.0001). Incisional biopsy did not adversely affect prognosis in terms of local recurrence and mortality. Prognosis was related to tumour thickness, age and sex of the patient, and not to biopsy technique. We recommend that all suspicious lesions should be submitted to excisional rather than incisional biopsy to avoid compromising the histological assessment, given the importance of maximal tumour thickness in determining treatment and prognosis.
Authors:
V C Lees; J C Briggs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  78     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-10     Completed Date:  1991-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1108-10     Citation Subset:  AIM; IM    
Affiliation:
Department of Plastic Surgery, Addenbrooke's Hospital, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biopsy / methods*
Female
Humans
Incidence
Male
Melanoma / mortality,  pathology*
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Prognosis
Regression Analysis
Sex Factors
Skin / pathology*
Skin Neoplasms / mortality,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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