| Effect of inhibition of pentagastrin-stimulated acid secretion on gastric mucosal gland luminal pressure. | |
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MedLine Citation:
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PMID: 9179318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We demonstrated previously that hydrochloric acid secreted from the gastric glands traverses the mucus layer in channels above the gland openings. The driving force for creation of these channels is most probably the hydrostatic pressure generated in the gastric gland lumen during stimulation of acid secretion. Here we investigated the effect of total inhibition of acid secretion on gland luminal pressure. Glandular pressure was measured in vivo with a pressure-sensitive microelectrode technique in Inactin-anaesthetized Sprague Dawley or Lewis x DA F1 rats. Glandular pressure was significantly reduced after ranitidine inhibition of acid secretion, from 17.2 +/- 2.1 mmHg during pentagastrin stimulation to 11.2 +/- 1.2 mmHg. This was also true when pentagastrin infusion was continued after inhibition of secretion with ranitidine. Omeprazole, however, did not significantly alter gland luminal pressure although it totally inhibited acid secretion. With continuation of pentagastrin infusion after omeprazole inhibition, glandular pressure increased significantly from 17.6 +/- 3.4 to 20.1 +/- 3.3 mmHg. In conclusion, total inhibition of acid secretion with ranitidine reduces but does not abolish gland luminal pressure. After omeprazole inhibition of acid secretion the gastric gland luminal pressure persisted or even increased. Since the volume secretion is lower after omeprazole administration than during pentagastrin stimulation, the outflow resistance most probably had increased after omeprazole injection. Suggestions for increased outflow resistance are narrowing in the upper part of the gland lumen by conformational changes of the cells or muscle contractions, and/or an increase in mucus secretion or viscosity. |
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Authors:
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I Synnerstad; A E Persson; L Holm |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 160 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-17 Completed Date: 1997-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 103-11 Citation Subset: IM |
Affiliation:
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Department of Physiology and Medical Biophysics, Uppsala University, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Ulcer Agents / pharmacology* Gastric Acid / secretion* Gastric Mucosa / drug effects*, physiology* Hydrostatic Pressure Omeprazole / pharmacology Pentagastrin / pharmacology* Ranitidine / pharmacology Rats Rats, Inbred Lew Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 5534-95-2/Pentagastrin; 66357-35-5/Ranitidine; 73590-58-6/Omeprazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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