Document Detail

Effect of inhibition of nitric oxide synthesis on the cardiovascular and endocrine responses to hemorrhage in conscious rabbits.
MedLine Citation:
PMID:  7584911     Owner:  NLM     Status:  MEDLINE    
Nitric oxide plays an important role in the regulation of arterial pressure by its actions to dilate vascular smooth muscle, alter sympathetic neural activity, and modulate the vasoconstrictor action of norepinephrine, angiotensin II and vasopressin. Nitric oxide may also influence blood pressure regulation by altering the secretion of renin and vasopressin. To test this possibility, we investigated the effects of inhibiting nitric oxide synthesis on the cardiovascular, renin and vasopressin responses to hypotensive hemorrhage, a situation in which the renin-angiotensin system and vasopressin contribute significantly to the control of blood pressure. Arterial blood was withdrawn from conscious, chronically-prepared rabbits at 1.0 ml/kg/min for 15 min under control conditions, and during i.v. infusion of the nitric oxide synthase inhibitor L-NAME. Hemorrhage decreased mean arterial pressure from 69 +/- 2 to 45 +/- 4 mm Hg (p < 0.01) and increased heart rate from 211 +/- 10 to 270 +/- 15 bpm (p < 0.05). Plasma renin activity increased from 7.7 +/- 1 to 36.1 +/- 9.6 ng/ml/2h at 15 min (p < 0.01), while plasma vasopressin concentration increased from 1.7 +/- 0.6 to 183.2 +/- 98.5 pg/ml (p < 0.05). Infusion of L-NAME increased blood pressure and plasma vasopressin concentration, and decreased heart rate and plasma renin activity. L-NAME markedly attenuated the hypotensive response to hemorrhage (72 +/- 3 to 62 +/- 4 mmHg), but did not alter the increases in heart rate, plasma renin activity or plasma vasopressin concentration. In separate experiments, L-NAME did not alter the setpoint or gain of the baroreceptor reflex control of heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
T Chiu; I A Reid
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  18     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-12-27     Completed Date:  1995-12-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  55-61     Citation Subset:  IM    
Department of Physiology, University of California, San Francisco 94143-0444, USA.
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MeSH Terms
Arginine / analogs & derivatives,  pharmacology
Arginine Vasopressin / blood
Baroreflex / drug effects
Blood Pressure / drug effects
Enzyme Inhibitors / pharmacology
Hemorrhage / metabolism,  physiopathology*
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors*,  biosynthesis
Nitric Oxide Synthase / antagonists & inhibitors
Renin / blood
Grant Support
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 113-79-1/Arginine Vasopressin; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC Oxide Synthase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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