| Effect of inhibition of lipolysis on myocardial oxygen consumption in the presence of isoproterenol. | |
| | |
MedLine Citation:
|
PMID: 5564394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of intravenous infusion of isoproterenol on myocardial oxygen consumption (MVo(2)) was studied in 10 intact and anesthetized dogs before and after inhibition of lipolysis. In five dogs lipolysis was inhibited by nicotinic acid or beta pyridyl carbinol and in five other dogs by high plasma glucose concentrations. In spite of similar mechanical responses to isoproterenol, as evidenced by left ventricular pressure, maximal rate of rise of left ventricular pressure (dP/dt), heart rate and cardiac output, augmentation of MVo(2) was larger before (on average 7.6 ml/min.100 g) than after inhibition of lipolysis either by antilipolytic drugs (on average 4.5 ml/min.100 g) (P < 0.005), or by high plasma glucose concentrations (on average 4.3 ml/min.100 g) (P < 0.02). As mechanical responses to isoproterenol were similar before and after inhibition of lipolysis, it is concluded that the additional rise in MVo(2) with intact lipolysis was caused by a metabolic stimulation by high concentrations of free fatty acids. |
| | |
Authors:
|
O D Mjos |
Related Documents
:
|
6333914 - Myocardial metabolism and haemodynamic responses with enflurane anaesthesia for coronar... 14734384 - Best evidence topic reports. oxygen in acute uncomplicated myocardial infarction. 16215384 - Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in se... 485694 - Myocardial biochemical modifications induced by theophylline with reference to its valu... 20734444 - Periprocedural myocardial infarction: review and classification. 3025824 - Neuropeptide y (npy) and the pig heart: release and coronary vasoconstrictor effects. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 50 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1971 Sep |
Date Detail:
|
Created Date: 1971-10-14 Completed Date: 1971-10-14 Revised Date: 2010-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1869-73 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Cardiac Output / drug effects Depression, Chemical Dogs Fatty Acids, Nonesterified / metabolism Female Heart Rate / drug effects Isoproterenol / pharmacology* Lipid Metabolism* Male Methanol Myocardium / metabolism* Nicotinic Acids / pharmacology Oxygen Consumption / drug effects* Pyridines / pharmacology Vasodilator Agents / pharmacology Ventricular Function |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Nonesterified; 0/Nicotinic Acids; 0/Pyridines; 0/Vasodilator Agents; 67-56-1/Methanol; 7683-59-2/Isoproterenol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sepcific removal of in vivo antibody by extracorporeal circulation over an immunoadsorbent in gel.
Next Document: Functional evaluation of an inherited abnormal fibrinogen: fibrinogen "Baltimore".