Document Detail


Effect of inhaled steroids on cholinergic transmission in human isolated bronchi.
MedLine Citation:
PMID:  7664858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Steroids have been found to facilitate cholinergic transmission in skeletal muscle, but possible effects in airways smooth muscles have not been studied. Therefore, choline acetyltransferase (CAT) activity, tissue content of stored acetylcholine and release of newly-synthesized [3H]acetylcholine were were measured in freshly-dissected human bronchi. All lung tissue was obtained from patients with lung cancer at thoracotomy. Group I bronchi were obtained from patients who also suffered from chronic obstructive bronchitis and had been treated for at least 6 weeks before surgery with daily doses of four puffs of flusinolid. Group II bronchi were obtained from patients who did not suffer from chronic obstructive airways disease and had not been treated with steroids. Neither CAT activity (3.1 nmol.h-1.mg protein-1) nor acetylcholine tissue content (260 pmol.100 mg-1), or electrically evoked [3H]acetylcholine release (about 2,000 dpm.100 mg-1) differed in the two groups. This cross sectional study indicates that inhaled steroids do not change cholinergic transmission beyond the level observed in the airways obtained from patients with lung cancer who do not suffer from chronic airways disease and have not been treated with inhaled steroids. This suggests that inhaled steroids can be given chronically without the induction of a facilitatory side-effect on cholinergic transmission within the airways.
Authors:
J Rícný; K D Höhle; K Racké; I Wessler
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  8     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-10-06     Completed Date:  1995-10-06     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  587-9     Citation Subset:  IM    
Affiliation:
Dept of Pharmacology, University of Mainz, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism*
Administration, Inhalation
Aged
Bronchi / drug effects,  innervation*,  metabolism
Bronchitis / drug therapy,  physiopathology
Case-Control Studies
Choline O-Acetyltransferase / metabolism*
Female
Humans
Lung Neoplasms / physiopathology
Male
Middle Aged
Parasympathetic Nervous System / drug effects*,  physiology
Steroids / pharmacology*,  therapeutic use
Synaptic Transmission / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Steroids; 0/flusinolid; 51-84-3/Acetylcholine; EC 2.3.1.6/Choline O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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