Document Detail


Effect of inhaled hydrogen sulfide on metabolic responses in anesthetized, paralyzed, and mechanically ventilated piglets.
MedLine Citation:
PMID:  18477923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Induced hypometabolism may improve the balance between oxygen delivery and consumption and may help sustain tissue viability in critically ill patients with low cardiac output state. Inhaled hydrogen sulfide (H2S) has been shown to induce a suspended animation-like state in mice with a 90% decrease in oxygen consumption. We conducted a preclinical study to explore the potential effect of H2S on metabolic rate in large mammals. DESIGN: Prospective study. SETTING: Animal laboratory in a university hospital. SUBJECTS: Eleven anesthetized, paralyzed, and mechanical ventilated piglets (5.8 +/- 0.7 kg). INTERVENTIONS: The right carotid artery and superior vena cava were cannulated for arterial pressure monitoring and blood gas sampling. Seven piglets were sequentially exposed to 20, 40, 60, and 80 ppm of H2S over a period of 6 hrs (each level for 1.5 hrs) (H2S group), and additionally four piglets were exposed to air over the same period (control group). MEASUREMENTS AND MAIN RESULTS: Ambient temperature was fixed at 22 degrees C throughout. Central body temperature, arterial pressure, and heart rate were continuously monitored. Oxygen consumption and carbon dioxide production were continuously measured using respiratory mass spectrometry. Cardiac output was calculated using the Fick principle. Central temperature and oxygen consumption significantly and linearly decreased over the H2S exposures (p < .0001 for both), the rates of which were significantly less compared with those in the control group (p < .01 for both). Mean arterial pressure increased significantly (p = .007), whereas heart rate (p = .14), cardiac output (p = .89), and lactate (p = .67) did not change significantly during H2S exposures in H2S group; all the variables decreased significantly in the control group (p < .01 for all), and p < .01 by comparison with H2S group except for lactate (p = .05). CONCLUSIONS: H2S does not appear to have hypometabolic effects in ambiently cooled large mammals and conversely appears to act as a hemodynamic and metabolic stimulant.
Authors:
Jia Li; Gencheng Zhang; Sally Cai; Andrew N Redington
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  9     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-05-14     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-2     Citation Subset:  IM    
Affiliation:
Cardiac Program, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Anesthesia*
Animals
Carbon Dioxide / analysis,  metabolism
Cardiac Output
Heart Rate
Hydrogen Sulfide / administration & dosage*,  pharmacology*
Hypothermia, Induced
Ischemia / prevention & control
Lactic Acid / analysis,  blood
Monitoring, Physiologic / methods,  veterinary
Oxygen Consumption*
Paralysis*
Prospective Studies
Respiration, Artificial*
Swine
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7783-06-4/Hydrogen Sulfide
Comments/Corrections
Comment In:
Pediatr Crit Care Med. 2008 Jan;9(1):129-30   [PMID:  18185132 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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