Document Detail


Effect of an inhaled glucocorticoid on endothelial function in healthy smokers.
MedLine Citation:
PMID:  18467553     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cigarette smoking is associated with attenuated endothelium-dependent vasodilation (endothelial dysfunction) in the systemic circulation, including the airway circulation. We wished to determine whether an inhaled corticosteroid could restore endothelial function in the airway of lung-healthy current smokers, ex-smokers, and nonsmokers. We measured baseline airway blood flow (Qaw) and Qaw reactivity to inhaled albuterol as an index of endothelium-dependent vasodilation and to sublingual nitroglycerin as an index of endothelium-independent vasodilation in lung-healthy current smokers, ex-smokers, and nonsmokers. Current smokers were then treated with inhaled fluticasone for 3 wk, and all measurements were repeated after fluticasone treatment and after a subsequent 3-wk fluticasone washout period. Baseline mean Qaw and endothelium-independent Qaw reactivity were similar in the three groups. Mean endothelium-dependent Qaw reactivity was 49.5% in nonsmokers, 42.7% in ex-smokers, and 10.8% in current smokers (P < 0.05 vs. nonsmokers). In current smokers, mean baseline Qaw was unchanged after fluticasone treatment, but endothelium-dependent Qaw reactivity significantly increased to 34.9%. Qaw reactivity was again blunted after fluticasone washout. Endothelial dysfunction, as assessed by vascular reactivity, can be corrected with an inhaled corticosteroid in the airway of lung-healthy current smokers. This proof of concept can serve as the basis for future clinical investigations on the effect of glucocorticoids on endothelial function in smokers.
Authors:
Eliana S Mendes; Gabor Horvath; Patricia Rebolledo; Maria Elena Monzon; S Marina Casalino-Matsuda; Adam Wanner
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Publication Detail:
Type:  Journal Article     Date:  2008-05-08
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  105     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-09-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. emendes@med.miami.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adolescent
Adult
Albuterol / administration & dosage,  pharmacology
Androstadienes / administration & dosage,  pharmacology*
Bronchodilator Agents / administration & dosage,  pharmacology*
Endothelium / drug effects*
Female
Forced Expiratory Volume / drug effects,  physiology
Glucocorticoids / administration & dosage,  pharmacology*
Humans
Male
Middle Aged
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects
Nitroglycerin / pharmacology
Regional Blood Flow / drug effects
Respiratory Function Tests
Respiratory System / blood supply
Smoking / physiopathology*
Spirometry
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Androstadienes; 0/Bronchodilator Agents; 0/Glucocorticoids; 0/Vasodilator Agents; 18559-94-9/Albuterol; 55-63-0/Nitroglycerin; CUT2W21N7U/fluticasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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