| Effect of inhaled 239PuO2 on alveolar type II cells. | |
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MedLine Citation:
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PMID: 2569019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphological changes of rat alveolar type II (AT-II) cells were studied at 8 and 10 months following inhalation of 239PuO2 to elucidate the biological role of AT-II cells in the induction of lung tumours. TEM micrographs of random sections of lung were analysed qualitatively and quantitatively using an automatic image analyser. Eighteen morphometric parameters were obtained according to stereological principles. The results showed that, following the inhalation of 239PuO2, AT-II cells became less differentiated and the metabolism of the pulmonary surfactant in AT-II cells was disturbed. |
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Authors:
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Z Y Shen; C Q Ye; D C Wu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation biology Volume: 56 ISSN: 0955-3002 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-05 Completed Date: 1989-09-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 169-78 Citation Subset: IM; S |
Affiliation:
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Department of Radiotoxicology, Institute of Radiation Medicine, Beijing, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Animals Cell Differentiation / radiation effects Cell Division / radiation effects Cell Nucleus / ultrastructure Cytoplasm / ultrastructure Male Mitochondria / ultrastructure Plutonium / toxicity* Pulmonary Alveoli / cytology, radiation effects*, ultrastructure Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 7440-07-5/Plutonium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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