| Effect of ingestion of eicosapentaenoic acid ethyl ester on carrageenan-induced colitis in guinea pigs. | |
| | |
MedLine Citation:
|
PMID: 1316857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of highly purified eicosapentaenoic acid ethyl ester (EPA-E) on colitis was investigated using a guinea pig model. The technique for preparing a degraded carrageenan with a molecular weight of about 30,000 from commercial iota-carrageenan was first refined. When this degraded carrageenan was fed to guinea pigs, localized ulcerations occurred in the cecum with infiltration of numerous mononuclear phagocytes. Oral administration of 300 mg.kg-1.day-1 of EPA-E for 3 weeks significantly prevented the development of colitis. The amounts of prostaglandin E2, thromboxane B2, and leukotriene B4 released from the cecal mucosa were also measured. The release of prostaglandin E2 and thromboxane B2 was significantly decreased in the animals fed EPA-E compared with those given olive oil or a vehicle alone. In addition, there was a positive correlation between the amounts of these eicosanoids and the degree of ulcer formation. However, there was no difference in the amount of leukotriene B4 among various experimental groups of animals. Furthermore, EPA-E feeding induced a significant decrease in the level of arachidonic acid and a significant increase in that of EPA in peritoneal macrophages. These results suggest that EPA has a prophylactic effect on the development of carrageenan-induced colitis, which may be ascribed in part to reduced eicosanoid production. |
| | |
Authors:
|
Y Kitsukawa; H Saito; Y Suzuki; J Kasanuki; Y Tamura; S Yoshida |
Related Documents
:
|
10898597 - Phosphobutyrylcholinesterase: phosphorylation of the esteratic site of butyrylcholinest... 11108547 - The uterotonic activity of compounds isolated from the supercritical fluid extract of e... 1975837 - Excitatory amino acid-induced formation of inositol phosphates in guinea-pig cerebral c... 7306027 - Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis ... 21325047 - Essential role for protein kinase c{zeta} in oleic acid-induced glucagon-like peptide-1... 3567987 - Structural characterisation of an anti-complementary arabinogalactan from the roots of ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Gastroenterology Volume: 102 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1992 Jun |
Date Detail:
|
Created Date: 1992-06-19 Completed Date: 1992-06-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1859-66 Citation Subset: AIM; IM |
Affiliation:
|
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight / drug effects Carrageenan Cecal Diseases / chemically induced Colitis / chemically induced, prevention & control* Dinoprostone / physiology Dose-Response Relationship, Drug Eicosapentaenoic Acid / analogs & derivatives*, therapeutic use Fatty Acids / analysis Guinea Pigs Leukotriene B4 / physiology Macrophages / chemistry Male Occult Blood Thromboxane B2 / physiology Ulcer / chemically induced |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 1553-41-9/Eicosapentaenoic Acid; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 71160-24-2/Leukotriene B4; 73310-10-8/eicosapentaenoic acid ethyl ester; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Insulin can rapidly increase cell surface insulin binding capacity in rat adipocytes. A novel mechan...
Next Document: The risk of upper gastrointestinal cancer in familial adenomatous polyposis.