Document Detail

Effect of ingestion of eicosapentaenoic acid ethyl ester on carrageenan-induced colitis in guinea pigs.
MedLine Citation:
PMID:  1316857     Owner:  NLM     Status:  MEDLINE    
The effect of highly purified eicosapentaenoic acid ethyl ester (EPA-E) on colitis was investigated using a guinea pig model. The technique for preparing a degraded carrageenan with a molecular weight of about 30,000 from commercial iota-carrageenan was first refined. When this degraded carrageenan was fed to guinea pigs, localized ulcerations occurred in the cecum with infiltration of numerous mononuclear phagocytes. Oral administration of 300 of EPA-E for 3 weeks significantly prevented the development of colitis. The amounts of prostaglandin E2, thromboxane B2, and leukotriene B4 released from the cecal mucosa were also measured. The release of prostaglandin E2 and thromboxane B2 was significantly decreased in the animals fed EPA-E compared with those given olive oil or a vehicle alone. In addition, there was a positive correlation between the amounts of these eicosanoids and the degree of ulcer formation. However, there was no difference in the amount of leukotriene B4 among various experimental groups of animals. Furthermore, EPA-E feeding induced a significant decrease in the level of arachidonic acid and a significant increase in that of EPA in peritoneal macrophages. These results suggest that EPA has a prophylactic effect on the development of carrageenan-induced colitis, which may be ascribed in part to reduced eicosanoid production.
Y Kitsukawa; H Saito; Y Suzuki; J Kasanuki; Y Tamura; S Yoshida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  102     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-06-19     Completed Date:  1992-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1859-66     Citation Subset:  AIM; IM    
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
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MeSH Terms
Body Weight / drug effects
Cecal Diseases / chemically induced
Colitis / chemically induced,  prevention & control*
Dinoprostone / physiology
Dose-Response Relationship, Drug
Eicosapentaenoic Acid / analogs & derivatives*,  therapeutic use
Fatty Acids / analysis
Guinea Pigs
Leukotriene B4 / physiology
Macrophages / chemistry
Occult Blood
Thromboxane B2 / physiology
Ulcer / chemically induced
Reg. No./Substance:
0/Fatty Acids; 1553-41-9/Eicosapentaenoic Acid; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 71160-24-2/Leukotriene B4; 73310-10-8/eicosapentaenoic acid ethyl ester; 9000-07-1/Carrageenan

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