Document Detail


Effect of inflammation induced by prolonged exercise on circulating erythroid progenitors and markers of erythropoiesis.
MedLine Citation:
PMID:  20001441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Exercise in humans augments the mobilization of circulating hematopoietic progenitor cells (CD34(+)) from the bone marrow. We investigated the effect of inflammation on erythroid marrow activity by mobilization of erythroid progenitor cells (EPs) along with soluble markers of erythropoiesis. METHODS: Ten healthy athletes who participated in an ultradistance foot race participated in the study. Peripheral blood mononuclear cells were isolated, before (phase I), at the end (phase II), and at 48 h post-race (phase III). EPs were detected as burst colony forming units (BFU-e) and colonies were scored at day 14. Markers of inflammation (C-reactive protein, serum amyloid-A, interleukin-6, ferritin and S100B) and bone marrow activity (erythropoietin, soluble transferrin receptor and lipocalin-2) were assessed. RESULTS: An approximately three-fold decrease in BFU-e number was observed at phase II. sTfR concentrations were also decreased at phase II and remained decreased at phase III. However, EPO and lipocalin-2 concentrations reached a maximum value at phase II, with a tendency to decrease at phase III. CONCLUSIONS: These findings indicate that exercise-induced inflammation modulates bone marrow homeostasis leading to an increase in leukocyte turnover and a decrease in erythroid compartment. It appears that lipocalin-2 is the main factor that regulates the production and mobilization of EPs.
Authors:
Antonia Spiropoulos; Evgenios Goussetis; Alexandra Margeli; Evangelos Premetis; Katerina Skenderi; Stelios Graphakos; Panayiotis Baltopoulos; Maria Tsironi; Ioannis Papassotiriou
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  48     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Affiliation:
Stem Cell Transplant Unit, Aghia Sophia Children's Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / immunology,  metabolism
Athletes
Biological Markers / blood*
Bone Marrow / immunology,  metabolism,  pathology
Erythroid Precursor Cells / immunology,  metabolism*,  pathology*
Erythropoiesis / immunology,  physiology*
Erythropoietin / blood
Ferritins / blood
Humans
Inflammation / blood*,  etiology,  immunology
Lipocalins / immunology,  metabolism
Physical Exertion / physiology*
Proto-Oncogene Proteins / immunology,  metabolism
Receptors, Transferrin / blood
Running / injuries*
Time Factors
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 0/Receptors, Transferrin; 11096-26-7/Erythropoietin; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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