| Effect of inflammation induced by prolonged exercise on circulating erythroid progenitors and markers of erythropoiesis. | |
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MedLine Citation:
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PMID: 20001441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Exercise in humans augments the mobilization of circulating hematopoietic progenitor cells (CD34(+)) from the bone marrow. We investigated the effect of inflammation on erythroid marrow activity by mobilization of erythroid progenitor cells (EPs) along with soluble markers of erythropoiesis. METHODS: Ten healthy athletes who participated in an ultradistance foot race participated in the study. Peripheral blood mononuclear cells were isolated, before (phase I), at the end (phase II), and at 48 h post-race (phase III). EPs were detected as burst colony forming units (BFU-e) and colonies were scored at day 14. Markers of inflammation (C-reactive protein, serum amyloid-A, interleukin-6, ferritin and S100B) and bone marrow activity (erythropoietin, soluble transferrin receptor and lipocalin-2) were assessed. RESULTS: An approximately three-fold decrease in BFU-e number was observed at phase II. sTfR concentrations were also decreased at phase II and remained decreased at phase III. However, EPO and lipocalin-2 concentrations reached a maximum value at phase II, with a tendency to decrease at phase III. CONCLUSIONS: These findings indicate that exercise-induced inflammation modulates bone marrow homeostasis leading to an increase in leukocyte turnover and a decrease in erythroid compartment. It appears that lipocalin-2 is the main factor that regulates the production and mobilization of EPs. |
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Authors:
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Antonia Spiropoulos; Evgenios Goussetis; Alexandra Margeli; Evangelos Premetis; Katerina Skenderi; Stelios Graphakos; Panayiotis Baltopoulos; Maria Tsironi; Ioannis Papassotiriou |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 48 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
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Languages: eng Pagination: 199-203 Citation Subset: IM |
Affiliation:
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Stem Cell Transplant Unit, Aghia Sophia Children's Hospital, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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immunology,
metabolism Athletes Biological Markers / blood* Bone Marrow / immunology, metabolism, pathology Erythroid Precursor Cells / immunology, metabolism*, pathology* Erythropoiesis / immunology, physiology* Erythropoietin / blood Ferritins / blood Humans Inflammation / blood*, etiology, immunology Lipocalins / immunology, metabolism Physical Exertion / physiology* Proto-Oncogene Proteins / immunology, metabolism Receptors, Transferrin / blood Running / injuries* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Biological Markers; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 0/Receptors, Transferrin; 11096-26-7/Erythropoietin; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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