Document Detail


Effect on infant mortality of iodination of irrigation water in a severely iodine-deficient area of China.
MedLine Citation:
PMID:  9297997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hotien county in Xinjiang province, China, is an area of severe iodine deficiency and has a high infantmortality rate. We investigated whether iodine replacement through iodination of the irrigation water would decrease infant mortality. METHODS: We added potassium iodate to irrigation water over a 2 to 4 week period beginning in 1992 in certain areas of three townships (Tusala, Long Ru, and Bakechi). Logistic regression analysis was used to compare the odds ratios for infant and neonatal mortality in treated and intreated areas. FINDINGS: The median urinary iodine concentration significantly increased in women of child-bearing age from < 10 micrograms/L to 55 micrograms/L. Infant-mortality rates decreased in the treated areas of Long Ru (mean [SD] 58.2 [4.4] per 1000 births to 28.7 [7.1] per 1000 births), Tusala (47.4 [12.4] per 1000 births to 19.1 [1.5] per 1000 births), and Bakechi (106.2 [9.5] per 1000 births to 57.3 [7.3] per 1000 births). Similar results were also seen for neonatal mortality. On regression analysis iodine treatment and time were significant independent predictors of infant mortality. INTERPRETATION: Iodine supplementation of irrigation water in areas of severe iodine deficiency decreases neonatal and infant mortality. Iodine replacement has probably been an important factor in the national decrease in infant mortality in China.
Hotien county in Xinjiang province is an area of severe iodine deficiency which also has a high infant mortality rate (IMR). The authors investigated whether iodine replacement through iodination of irrigation water would decrease the level of infant mortality. Potassium iodine was added to irrigation water over a 2-4 week period beginning in 1992 in certain areas of Long Ru, Tusala, and Bakechi. The median urinary iodine concentration significantly increased in women of child-bearing age from less than 10 mg/l to 55 mg/l, while IMR decreased in Long Ru from a mean of 58.2/1000 births to 28.7/1000, in Tusala from 47.4/1000 to 19.1/1000, and in Bakechi from 106.2/1000 to 57.3/1000. Similar results were also observed for neonatal mortality. Iodine treatment and time were significant independent predictors of infant mortality.
Authors:
G R DeLong; P W Leslie; S H Wang; X M Jiang; M L Zhang; M Rakeman; J Y Jiang; T Ma; X Y Cao
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  350     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-14     Completed Date:  1997-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  771-3     Citation Subset:  AIM; IM; J    
Affiliation:
Division of Pediatric Neurology, Duke University Medical Center, Durham NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Agriculture*
China / epidemiology
Female
Humans
Infant
Infant Mortality*
Infant, Newborn
Iodates*
Iodine / deficiency*,  urine
Potassium Compounds*
Pregnancy
Regression Analysis
Rural Health
Water Supply
Chemical
Reg. No./Substance:
0/Iodates; 0/Potassium Compounds; 7553-56-2/Iodine; 7758-05-6/potassium iodate
Comments/Corrections
Comment In:
Lancet. 1997 Nov 15;350(9089):1482; author reply 1482   [PMID:  9371198 ]
Lancet. 1997 Nov 15;350(9089):1481-2; author reply 1482   [PMID:  9371197 ]

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