Document Detail


Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women.
MedLine Citation:
PMID:  21795740     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel intervention study with the objective to examine the effect of IP-TFA intake on biomarkers of inflammation, oxidative stress, and endothelial dysfunction. Fifty-two healthy overweight postmenopausal women (49 completers) were randomly assigned to receive either partially hydrogenated soybean oil (15.7 g/day IP-TFA) or control oil without IP-TFA. After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF) α by 12% [95% confidence interval (CI): 5-20; P = 0.002] more in the IP-TFA group compared with controls. Plasma soluble TNF receptors 1 and 2 were also increased by IP-TFA [155 pg/ml (CI: 63-247); P < 0.001 and 480 pg/ml (CI: 72-887); P = 0.02, respectively]. Serum C-reactive protein, interleukin (IL) 6 and adiponectin and subcutaneous abdominal adipose tissue mRNA expression of IL6, IL8, TNFα, and adiponectin as well as ceramide content were not affected by IP-TFA, nor was urinary 8-iso-prostaglandin-F(2α). In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNFα system.
Authors:
Nathalie T Bendsen; Steen Stender; Pal B Szecsi; Steen B Pedersen; Samar Basu; Lars I Hellgren; John W Newman; Thomas M Larsen; Steen B Haugaard; Arne Astrup
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-27
Journal Detail:
Title:  Journal of lipid research     Volume:  52     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2012-01-12     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1821-8     Citation Subset:  IM    
Affiliation:
Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark. nathalie@life.ku.dk
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00655902
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Cardiovascular Diseases / drug therapy,  metabolism,  pathology
Dietary Fats, Unsaturated / administration & dosage,  metabolism
Double-Blind Method
Endothelium / drug effects*,  metabolism
Female
Food Industry*
Humans
Hydrogenation
Inflammation / chemically induced,  metabolism*,  pathology
Middle Aged
Overweight / metabolism
Oxidative Stress / drug effects*
Postmenopause / metabolism
Receptors, Tumor Necrosis Factor, Type I / blood
Receptors, Tumor Necrosis Factor, Type II / blood
Risk Factors
Soybean Oil / administration & dosage,  chemistry
Time Factors
Trans Fatty Acids / administration & dosage*,  metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Dietary Fats, Unsaturated; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Receptors, Tumor Necrosis Factor, Type II; 0/Trans Fatty Acids; 8001-22-7/Soybean Oil
Comments/Corrections

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