Document Detail

Effect of industrial solvent exposure on blood pressure and liver ultrasound echogenicity.
MedLine Citation:
PMID:  17373261     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Industrial solvent exposure has been suggested to elevate blood pressure and to be associated with fatty liver disease. The mechanism of action is poorly known, as is the contribution of individual solvents. METHODS: Twenty-six workers with long-term solvent exposure and 19 unexposed volunteers were recruited. A detailed exposure assessment was performed, blood pressure was measured, and liver ultrasound echogenicity was scored as a proxy for its fatty degeneration. RESULTS: The mean values of systolic blood pressure of the study groups were within the normal range. Lifetime exposure was the decisive factor for blood pressure elevation when age, alcohol consumption, body mass index, gender, and smoking were controlled. The higher the alcohol consumption, the weaker the elevating effect of exposure on systolic blood pressure. Out of the solvent groups, exposure to white spirit and alcohols elevated systolic blood pressure significantly (P = 0.004 and P = 0.014, respectively) when exposed workers were compared with the unexposed workers and referents. The elevating effect remained, although it was not as significant, when analyses were restricted to the worker group (P=0.088 and P=0.104). Echogenicity was not an intermediate variable between exposure and blood pressure. CONCLUSIONS: Long-term exposure to solvents may have an elevating effect on blood pressure, mainly unrelated to liver fatty change, but weakened by alcohol use. These results are tentative and should be studied further.
Ari Kaukiainen; Rami Martikainen; Katariina Luoma; Helena Taskinen; Karri Helin; Tapio Vehmas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  Suppl 2     ISSN:  0355-3140     ISO Abbreviation:  -     Publication Date:  2006  
Date Detail:
Created Date:  2007-03-21     Completed Date:  2007-04-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  54-60     Citation Subset:  IM    
Occupational Medicine, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland.
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MeSH Terms
Alcohol Drinking
Blood Pressure / drug effects*
Body Mass Index
Confounding Factors (Epidemiology)
Fatty Liver / chemically induced
Liver / drug effects*,  ultrasonography
Middle Aged
Occupational Exposure
Solvents / pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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