Document Detail

Effect of induction dose, lactation stage and body condition on tiletamine-zolazepam anaesthesia in adult female grey seals (Halichoerus grypus) under field conditions.
MedLine Citation:
PMID:  21508066     Owner:  NLM     Status:  MEDLINE    
Tiletamine-zolazepam (TZ) was used at a mean (sd) dose of 1.18 (0.15) mg/kg administered intramuscularly to anaesthetise adult female grey seals (Halichoerus grypus) under field conditions at three different stages during their lactation period. A significant correlation was observed between the induction dose and time to induction (r=-0.582, P=0.011). Stage of lactation had a significant effect on condition index (CI), calculated as axial girth divided by length (P<0.001), and time to induction (P=0.009). No effect of CI on induction or recovery time was demonstrated. Respiratory rate decreased during induction and increased significantly (P<0.001) during surgical biopsy of blubber. Recovery occurred after 32.5 (11.9) minutes. Minor complications (tremor, vocalisation and mild dyspnoea) were observed in a small number of cases, none of which required treatment.
S D Langton; S E Moss; P P Pomeroy; K E Borer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-20
Journal Detail:
Title:  The Veterinary record     Volume:  168     ISSN:  2042-7670     ISO Abbreviation:  Vet. Rec.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-29     Completed Date:  2011-07-28     Revised Date:  2012-05-10    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  England    
Other Details:
Languages:  eng     Pagination:  457     Citation Subset:  IM    
Royal Veterinary College, North Mymms, Hertfordshire, UK.
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MeSH Terms
Anesthesia Recovery Period
Anesthesia, Intravenous / veterinary*
Anesthetics / administration & dosage*
Animal Welfare
Animals, Wild
Body Constitution / physiology
Dose-Response Relationship, Drug
Drug Combinations
Infusions, Intravenous / veterinary
Lactation / physiology*
Respiratory Rate / drug effects
Seals, Earless / physiology*
Tiletamine / administration & dosage*
Zolazepam / administration & dosage*
Reg. No./Substance:
0/Anesthetics; 0/Drug Combinations; 0/tiletamine, zolazepam drug combination; 14176-49-9/Tiletamine; 31352-82-6/Zolazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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