Document Detail

Effect of indomethacin on lymphocyte response to mitogens in puromycin aminonucleoside nephrosis in the rat.
MedLine Citation:
PMID:  7172499     Owner:  NLM     Status:  MEDLINE    
The mitogen response of peripheral blood lymphocytes to phytohaemagglutinin is depressed in rats with nephrotic syndrome induced by the administration of the aminonucleoside of puromycin. The mitogen response is normal after the administration of aminonucleoside of puromycin, but before the nephrotic syndrome develops. Nephrotic syndrome serum depresses the mitogen response of normal lymphocytes. This effect is attenuated by treatment of nephrotic rats with indomethacin, independently of any change in plasmas albumin concentration. Indomethacin in vitro has no effect. These studies suggest that the impaired response of nephrotic lymphocytes to phytohaemagglutinin is a secondary consequence of the nephrotic state, probably attributable, at least in part, to increased prostaglandin production in the nephrotic syndrome.
E H Garin; T M Barratt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  49     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  639-44     Citation Subset:  IM    
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MeSH Terms
Indomethacin / pharmacology*
Lymphocyte Activation / drug effects*
Nephrotic Syndrome / chemically induced,  immunology*,  metabolism
Proteinuria / metabolism
Puromycin Aminonucleoside
Rats, Inbred Strains
Serum Albumin / analysis
Reg. No./Substance:
0/Serum Albumin; 53-86-1/Indomethacin; 58-60-6/Puromycin Aminonucleoside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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