Document Detail

Effect of independent changes in mixed-venous PCO2 or PO2 on cardiac output in anesthetized sheep.
MedLine Citation:
PMID:  9299277     Owner:  NLM     Status:  MEDLINE    
To determine whether changes mixed-venous PCO2 or PO2 affect cardiac output independent of changes in arterial blood gases, we used extracorporeal gas exchange to increase mixed-venous PCO2 or decrease mixed-venous PO2 in adult sheep. Sheep were anesthetized, mechanically ventilated, and connected to a veno-venous extracorporeal circuit. The circuit included a gas exchanger which was used to increase mixed-venous PCO2 or decrease mixed-venous PO2; the native lungs were ventilated to maintain arterial PCO2 and PO2 at control levels. When mixed-venous PCO2 was increased by 32% above control levels for a period of 60 min, cardiac output increased significantly to 28% above control levels. Cervical vagotomy abolished this response. In contrast, decreasing mixed-venous PO2 by 29% did not increase cardiac output. These results demonstrate that increasing mixed-venous PCO2 can increase cardiac output independent of changes in arterial blood gases and that intact vagus nerves are necessary for this response to occur.
C J Shanley; N L Shah; M C Overbeck; N B Kulkarni; R H Bartlett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of surgical research     Volume:  71     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-09     Completed Date:  1997-10-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
Copyright Information:
Copyright 1997 Academic Press.
Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
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MeSH Terms
Carbon Dioxide / blood*
Cardiac Output*
Oxygen / blood*
Respiration, Artificial
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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