Document Detail

Effect of indapamide on left ventricular hypertrophy in hypertension: a meta-analysis.
MedLine Citation:
PMID:  8848988     Owner:  NLM     Status:  MEDLINE    
Left ventricular hypertrophy is a major risk factor for cardiovascular morbidity and mortality. Angiotensin-converting enzyme inhibitors, calcium antagonists, and beta-blockers prevent, and cause regression of, left ventricular hypertrophy after short-term therapy. The ability of diuretics to do the same is unclear. We have performed a meta-analysis of studies documenting the effect on left ventricular mass of 6 months' treatment with 2.5 mg indapamide daily. Six studies comprising 197 patients, aged 20-75 years, were included. There was an overall mean reduction in left ventricular mass index of 13.3%, which was principally due to a reduction in left ventricular wall thickness rather than internal diameter.
P A Carey; D J Sheridan; A de Cordoue; D Guez
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis    
Journal Detail:
Title:  The American journal of cardiology     Volume:  77     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17b-19b     Citation Subset:  AIM; IM    
Academic Cardiology Unit, St. Mary's Hospital Medical School, Paddington, London, United Kingdom.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Diuretics / therapeutic use*
Dose-Response Relationship, Drug
Hypertension / drug therapy*
Hypertrophy, Left Ventricular / prevention & control*,  ultrasonography
Indapamide / therapeutic use*
Middle Aged
Risk Factors
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Diuretics; 26807-65-8/Indapamide

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