Document Detail

Effect of increasing the fat content but not the energy load of a meal on gastro-oesophageal reflux and lower oesophageal sphincter motor function.
MedLine Citation:
PMID:  9577336     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although fatty foods are commonly considered detrimental in patients with reflux disease, no objective data exist that substantiate this belief. AIMS: To investigate the effect of fat on gastro-oesophageal reflux and lower oesophageal sphincter (LOS) motor activity. SUBJECTS: Thirteen healthy subjects and 14 patients with reflux disease. METHODS: Oesophageal pH, LOS, and oesophageal pressures were recorded for 180 minutes after a high fat (52% fat) and a balanced (24% fat) meal (both 3.18 MJ) on two different occasions. Eight controls and seven patients were studied in the recumbent position and the others in the sitting position. RESULTS: The percentage of time at pH less than 4 and the rate of reflux episodes were higher (p < 0.01) in the patients than in the healthy subjects (mean 14.1% versus 1.7% and 4.4/h versus 0.8/h respectively), as was the percentage of transient LOS relaxations associated with reflux (62% versus 32%, p < 0.01). The high fat meal did not increase the rate of reflux episodes nor exposure to oesophageal acid in either group regardless of body posture. The rate of transient LOS relaxations, their association with reflux, and basal LOS pressure were also unaffected. CONCLUSIONS: Increasing fat intake does not affect gastro-oesophageal reflux or oesophagogastric competence for at least three hours after a meal.
R Penagini; M Mangano; P A Bianchi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  42     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-05-14     Completed Date:  1998-05-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  330-3     Citation Subset:  AIM; IM    
Cattedra di Gastroenterologia, University of Milan-IRCCS Ospedale Maggiore, Italy.
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MeSH Terms
Case-Control Studies
Dietary Fats / administration & dosage,  adverse effects*
Esophagogastric Junction / physiopathology*
Food, Formulated
Gastroesophageal Reflux / physiopathology*
Hydrogen-Ion Concentration
Middle Aged
Reg. No./Substance:
0/Dietary Fats
Comment In:
Gut. 1998 Mar;42(3):318-9   [PMID:  9577333 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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