Document Detail

Effect of increasing dietary vitamin A on bone density in adult dogs.
MedLine Citation:
PMID:  9374313     Owner:  NLM     Status:  MEDLINE    
There has been an increase in vitamin A fortification of livestock feeds resulting in increased residual vitamin A in organ meats, which are often used in canned dog foods. The effect on bone density of feeding various concentrations of vitamin A in a canned dog food product was investigated. Thirty-two random-source dogs were assigned to four treatments in a randomized complete block design. The diets contained 15,000, 50,000, 116,000, or 225,000 IU vitamin A/1,000 kcal ME. Diets were fed up to 1 yr. Computed tomography was used to determine bone density of the right tibia at 0, 3, 6, 9, and 12 mo. Computed tomography is a more sensitive technique for determining bone density in vivo than conventional x-rays. There were no differences (P > .10) in tibia bone or marrow density in any of the dogs fed the various concentrations of vitamin A. There was no interaction of time x diet on bone density (P > .05) or bone marrow density (P > .05). In addition, there were no changes in serum alkaline phosphatase, calcium, or phosphorus. These results indicate that concentrations of vitamin A three times the recommended maximum safe amount (71,429 IU/1,000 kcal ME) are not detrimental to normal bone health in dogs. Therefore, these data support the hypothesis that canines are less sensitive to excess vitamin A in the diet than some other mammals.
J L Cline; G L Czarnecki-Maulden; J M Losonsky; C R Sipe; R A Easter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of animal science     Volume:  75     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-27     Completed Date:  1998-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2980-5     Citation Subset:  IM    
Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, 61801, USA.
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MeSH Terms
Alkaline Phosphatase / blood
Bone Density / drug effects*,  physiology
Calcium / blood
Diet / veterinary*
Dogs / blood,  physiology*
Dose-Response Relationship, Drug
Phosphorus / blood
Random Allocation
Tibia / pathology,  radiography
Time Factors
Tomography, X-Ray Computed
Vitamin A / administration & dosage,  pharmacology*
Reg. No./Substance:
11103-57-4/Vitamin A; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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