Document Detail

Effect of increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio on murine liver and peritoneal cell fatty acids and eicosanoid formation.
MedLine Citation:
PMID:  1995785     Owner:  NLM     Status:  MEDLINE    
An incremental increase in the dietary (n-3):(n-6) polyunsaturated fatty acid (PUFA) ratio from 0 to 1.93 in diets containing 15% fat (wt/wt) decreased the total (n-6) PUFA content of phospholipids of the liver and peritoneal cells (macrophage) in mice from 43.1 and 33.6 mol/100 mol to 16.0 and 12.3 mol/100 mol with a concomitant increase of 27.6 and 16.1 mol/100 mol in (n-3) PUFA, respectively. Consumption of (n-3) PUFA increased hepatic (n-3) PUFA levels without changing total PUFA (46.35 vs. 46.87 mol/100 mol), whereas macrophage PUFA levels were decreased. The synthesis of sulfidopeptide leukotrienes (SP-LT) (LTC4 and LTE4) was progressively reduced by increasing dietary (n-3) PUFA, i.e., there was a reduction of 76% in mice fed a diet containing a (n-3):(n-6) PUFA ratio of 1.93 compared with the control diet. The 5-series SP-LT (LTC5 and LTF5) were produced in all animals consuming (n-3) PUFA and accounted for 62% of all SP-LT synthesized in mice fed the diet containing a 1.93 (n-3):(n-6) PUFA ratio. Synthesis of 6-keto-prostaglandin F1 alpha decreased 81% in mice fed a diet containing a (n-3):(n-6) PUFA ratio of 1.93 whereas prostaglandin E2 synthesis decreased 44% in mice fed diets with (n-3):(n-6) ratios ranging from 0.41 to 1.93.
K S Broughton; J Whelan; I Hardardottir; J E Kinsella
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  121     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-26     Completed Date:  1991-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-64     Citation Subset:  IM    
Institute of Food Science, Cornell University, Ithaca, NY 14853.
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MeSH Terms
Dietary Fats, Unsaturated / administration & dosage*
Eicosanoids / biosynthesis*
Fatty Acids / analysis
Fatty Acids, Unsaturated / administration & dosage*
Leukotrienes / biosynthesis
Liver / chemistry*
Macrophages / chemistry*,  metabolism
Peritoneal Cavity / cytology
Phospholipids / analysis
Prostaglandins / biosynthesis
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Eicosanoids; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Leukotrienes; 0/Phospholipids; 0/Prostaglandins

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