Document Detail

Effect of increasing carbon chain length on organic acid transport by the choroid plexus: a potential factor in Reye's syndrome.
MedLine Citation:
PMID:  6402269     Owner:  NLM     Status:  MEDLINE    
Transport of the anionic herbicide 2,4-dichlorophenoxyacetic acid by choroid plexus is inhibited significantly by several short and medium chain acids. For both monocarboxylic and dicarboxylic homologs, inhibition clearly increases with chain length. It appears that organic acid compounds of longer chain length, higher brain uptake index, and highest inhibition of choroid plexus transport would be the ones producing the most significant increases in intracranial pressure in metabolic encephalopathy such as Reye's syndrome.
C S Kim; L A O'Tuama; J D Mann; C R Roe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  259     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  340-3     Citation Subset:  IM    
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MeSH Terms
2,4-Dichlorophenoxyacetic Acid / metabolism
3-Hydroxybutyric Acid
Acids / pharmacology*
Blood-Brain Barrier / drug effects
Choroid Plexus / drug effects,  metabolism*
Decanoic Acids / pharmacology
Hexanoic Acids / pharmacology
Hydroxybutyrates / pharmacology
Intracranial Pressure / drug effects
Molecular Weight
Octanoic Acids / pharmacology
Reye Syndrome / metabolism*
Tyrosine / pharmacology
Valproic Acid / pharmacology
Grant Support
Reg. No./Substance:
0/Acids; 0/Decanoic Acids; 0/Hexanoic Acids; 0/Hydroxybutyrates; 0/Octanoic Acids; 300-85-6/3-Hydroxybutyric Acid; 55520-40-6/Tyrosine; 94-75-7/2,4-Dichlorophenoxyacetic Acid; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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